{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:59:40Z","timestamp":1790996380037,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether human HLA\u2010homozygous induced pluripotent stem cell (iPSC)\u2010derived neural precursor cells (iPSC\u2010NPCs) can provide functional benefits in Huntington\u2019s disease (HD), we transplanted them into the YAC128 transgenic HD mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>CHAi001\u2010A, an HLA\u2010homozygous iPSC line (A*33:03\u2010B*44:03\u2010DRB1*13:02), was differentiated into neural precursor cells, and then, they were transplanted into 6\u00a0months\u2010old YAC128 mice. Various behavioural and histological analyses were performed for five months after transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Motor and cognitive functions were significantly improved in transplanted animals. Cells transplanted in the striatum showed multipotential differentiation. Five months after transplantation, the donor cells had differentiated into neurons, oligodendrocytes and astrocytes. Transplantation restored DARPP\u201032 expression, synaptophysin density, myelin basic protein expression in the corpus callosum and astrocyte function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Altogether, these results strongly suggest that iPSC\u2010NPCs transplantation induces neuroprotection and functional recovery in a mouse model of HD and should be taken forward for clinical trials in HD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.13082","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T11:05:24Z","timestamp":1624273524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Human iPSC\u2010derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4367-864X","authenticated-orcid":false,"given":"Hyun Jung","family":"Park","sequence":"first","affiliation":[{"name":"Department of Biomedical Science CHA Stem Cell Institute CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6502-4394","authenticated-orcid":false,"given":"Juhyun","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science CHA Stem Cell Institute CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4963-4955","authenticated-orcid":false,"given":"Jiwoo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science CHA Stem Cell Institute CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1187-0322","authenticated-orcid":false,"given":"Ji Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science CHA Stem Cell Institute CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Sook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology CHA Bundang Medical Center CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine CHA Bundang Medical Center CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine University of Rochester Medical Center Rochester NY USA"},{"name":"Center for Translational Neuromedicine University of Copenhagen Faculty of Health and Medical Science Copenhagen N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6597-8208","authenticated-orcid":false,"given":"Jihwan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science CHA Stem Cell Institute CHA University Seongnam\u2010si Korea"},{"name":"iPS Bio, Inc. 3F, 16 Daewangpangyo\u2010ro 712 Beon\u2010gil Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904239106"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.039"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.05.009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.11.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00628"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.05.005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11758"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0590-05.2005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0857-08.2008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2865"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg169"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.008"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.05.027"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.05.007"},{"issue":"4","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/brain\/awp006","article-title":"Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin","volume":"132","author":"Pouladi MA","year":"2009","journal-title":"Brain"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10339-011-0430-z"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092310411"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2015.08.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108077108"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2986-07.2008"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3691"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3693-15.2016"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.05.002"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00042.2016"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24174"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl261"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2017.1346079"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme-2018-0158"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0021-9"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.04.007"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.07.021"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1589-10.2010"},{"issue":"13","key":"e_1_2_9_35_1","first-page":"2621","article-title":"Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease","volume":"25","author":"Teo RT","year":"2016","journal-title":"Hum Mol Genet"},{"issue":"2","key":"e_1_2_9_36_1","first-page":"215","article-title":"Brain white\u2010matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease","volume":"47","author":"Ciarmiello A","year":"2006","journal-title":"J Nucl Med"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2013.11.009"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.08.004"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-017-1383-5"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4707-08.2009"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201695810"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)80043-9"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-011-9725-y"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01011.x"}],"container-title":["Cell Proliferation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpr.13082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cpr.13082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpr.13082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T11:10:50Z","timestamp":1693307450000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpr.13082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,21]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/cpr.13082"],"URL":"https:\/\/doi.org\/10.1111\/cpr.13082","archive":["Portico"],"relation":{},"ISSN":["0960-7722","1365-2184"],"issn-type":[{"value":"0960-7722","type":"print"},{"value":"1365-2184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,21]]},"assertion":[{"value":"2021-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13082"}}