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These patients were reassessed for a 60\u2010month follow\u2010up through systemic and ophthalmic examinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the patients experienced adverse reactions systemically or locally, except for two who had transiently high intraocular pressure post\u2010operation. Functional assessments demonstrated that all of the seven operated eyes had transiently increased or stable visual function 1\u20104\u00a0months after transplantation. At the last follow\u2010up visit, two of the seven eyes showed visual function loss than the baseline; however, one of them showed a stable visual acuity when compared with the change of fellow eye. Obvious small high reflective foci in the RPE layer were displayed after the transplantation, and maintained until the last visit. Interestingly, three categories of patients who were classified based on autofluorescence, exhibited distinctive patterns of morphological and functional change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Subretinal transplantation of hESC\u2010RPE in early\u2010stage STGD1 is safe and tolerated in the long term. Further investigation is needed for choosing proper subjects according to the multi\u2010model image and function assessments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.13100","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T12:46:37Z","timestamp":1628081197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["A phase I clinical trial of human embryonic stem cell\u2010derived retinal pigment epithelial cells for early\u2010stage Stargardt macular degeneration: 5\u2010years' follow\u2010up"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-9520","authenticated-orcid":false,"given":"Shi\u2010Ying","family":"Li","sequence":"first","affiliation":[{"name":"Southwest Hospital\/Southwest Eye Hospital Third Military Medical University (Army Medical University) Chongqing China"},{"name":"Key Laboratory of Visual Damage and Regeneration &amp; 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