{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:33:26Z","timestamp":1791869606591,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771665"],"award-info":[{"award-number":["31771665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070845"],"award-info":[{"award-number":["32070845"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Mice are widely used as an animal model for studying human uterine receptivity for embryo implantation. Although transcriptional changes related to mouse uterine receptivity have been determined by using bulk RNA\u2010seq, the data are of limited value because the uterus is a complex organ consisting of many cell types. Here, we aimed to decipher mouse uterine receptivity for embryo implantation at single\u2010cell resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Single\u2010cell RNA sequencing was performed for the pre\u2010receptive and the receptive mouse uterus. Gene expression profiles in luminal epithelium and glandular epithelium were validated by comparing against a published laser capture microdissection (LCM)\u2010coupled microarray dataset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We revealed 19 distinct cell clusters, including 3\u00a0stromal cell clusters, 2 epithelial cell clusters, 1\u00a0smooth muscle cell cluster, 4 endothelial cell clusters and 8 immune cell clusters. We identified global gene expression changes associated with uterine receptivity in each cell type. Additionally, we predicted signalling interactions for distinct cell types to understand the crosstalk between the blastocyst and the receptive uterus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data provide a valuable resource for deciphering the molecular mechanism underlying uterine receptivity in mice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.13128","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:44:27Z","timestamp":1635806667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Deciphering mouse uterine receptivity for embryo implantation at single\u2010cell resolution"],"prefix":"10.1111","volume":"54","author":[{"given":"Yi","family":"Yang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Gansu Agricultural University Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu\u2010Yang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory for Lingnan Modern Agriculture College of Veterinary Medicine South China Agricultural University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6948-2576","authenticated-orcid":false,"given":"Ji\u2010Long","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory for Lingnan Modern Agriculture College of Veterinary Medicine South China Agricultural University Guangzhou 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