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Real\u2010time quantitative polymerase chain reaction, western blotting, enzyme\u2010linked immunosorbent assay and double\u2010immunofluorescence labelling were employed to assess the expression of <jats:italic>RelA<\/jats:italic>, SIRT1, SIRT6, SIRT7 and pro\u2010inflammatory factors. Dental pulp fibroblasts (DPFs) were transfected with siRNA to assess the biological role of SIRT7. A pulpitis model was utilized to evaluate the in vivo curative effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preliminary results showed that RvE1 and LXA4 reduced the expression of <jats:italic>RelA<\/jats:italic> more markedly than other two SPMs. Both RvE1 and LXA4 treatment downregulated nuclear factor kappa B (NF\u2010\u03baB) activation and increased the expression of SIRT1, SIRT6 and SIRT7, more so in combination than alone. Double\u2010immunofluorescence labelling showed that SIRT7 co\u2010localized with p\u2010p65 and Ac\u2010p65 in the nucleus. Inhibiting ChemR23 and ALX reversed the expression of <jats:italic>RelA<\/jats:italic> mRNA, p\u2010p65 and Ac\u2010p65 proteins, pro\u2010inflammatory factors, SIRT1, SIRT6 and SIRT7. Silencing <jats:italic>SIRT7<\/jats:italic> significantly increased p\u2010p65 and Ac\u2010p65 protein levels and decreased SIRT1 and SIRT6 expression. In vivo experiments showed that combined administration of RvE1 and LXA4 promoted pulpitis markedly to resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combination of RvE1 and LXA4 effectively inhibited NF\u2010\u03baB activation by upregulating <jats:italic>SIRT7<\/jats:italic> expression in DPFs, leading to reduced production of pro\u2010inflammatory factors and promotion of pulpitis resolution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.13227","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T02:35:01Z","timestamp":1649730901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Combination of resolvin <scp>E1<\/scp> and lipoxin <scp>A4<\/scp> promotes the resolution of pulpitis by inhibiting <scp>NF\u2010\u03baB<\/scp> activation through upregulating sirtuin 7 in dental pulp fibroblasts"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6252-4246","authenticated-orcid":false,"given":"Xiaochen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Endodontics, School &amp; Hospital of Stomatology Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School &amp; Hospital of Stomatology Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School &amp; Hospital of Stomatology Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School &amp; Hospital of Stomatology Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School &amp; Hospital of Stomatology Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration  Shanghai 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