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There is still no effective treatment and prevention strategy for BRONJ. Inorganic nitrate, which is abundant in green vegetables, has been reported to be protective in multiple diseases. To investigate the effects of dietary nitrate on BRONJ\u2010like lesions in mice, we utilized a well\u2010established mouse BRONJ model, in which tooth extraction was performed. Specifically, 4\u2009mM sodium nitrate was administered in advance through drinking water to assess the short\u2010 and long\u2010term effects on BRONJ. Zoledronate injection could induce severe healing inhibition of the tooth extraction socket, while addition of pretreating dietary nitrate could alleviate the inhibition by reducing monocyte necrosis and inflammatory cytokines production. Mechanistically, nitrate intake increased plasma nitric oxide levels, which attenuated necroptosis of monocytes by downregulating lipid and lipid\u2010like molecule metabolism via a RIPK3 dependent pathway. Our findings revealed that dietary nitrate could inhibit monocyte necroptosis in BRONJ, regulate the bone immune microenvironment and promote bone remodelling after injury. This study contributes to the understanding of the immunopathogenesis of zoledronate and supports the feasibility of dietary nitrate for the clinical prevention of BRONJ.<\/jats:p>","DOI":"10.1111\/cpr.13395","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T04:44:46Z","timestamp":1677041086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dietary nitrate improves jaw bone remodelling in zoledronate\u2010treated mice"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0672-0565","authenticated-orcid":false,"given":"Wen","family":"Pan","sequence":"first","affiliation":[{"name":"Salivary Gland Disease Centre and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Beijing Laboratory of Oral Health Capital Medical University  Beijing China"},{"name":"Department of Biochemistry and Molecular Biology, 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