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This study investigated the cellular response of periodontal ligament stem cells (PDLSCs) to elevated levels of a specific fatty acid, namely, palmitic acid (PA). The mechanism by which PA exposure compromises the osteogenic potential of cells was also explored. It was found that exposure of PDLSCs to abundant PA led to decreased cell osteogenic differentiation. Given that long non\u2010coding RNAs (lncRNAs) play a key role in the stem cell response to adverse environmental stimuli, we screened the lncRNAs that were differentially expressed in PDLSCs following PA exposure using lncRNA microarray analysis, and <jats:italic>AC018926.2<\/jats:italic> was identified as the lncRNA that was most sensitive to PA. Next, gain\/loss\u2010of\u2010function studies illustrated that <jats:italic>AC018926.2<\/jats:italic> was an important regulator in PA\u2010mediated osteogenic differentiation of PDLSCs. Mechanistically, <jats:italic>AC018926.2<\/jats:italic> upregulated integrin \u03b12 (<jats:italic>ITGA2<\/jats:italic>) expression and therefore activated ITGA2\/FAK\/AKT signalling. Further functional studies revealed that inactivation of ITGA2\/FAK\/AKT signalling by silencing ITGA2 counteracted the pro\u2010osteogenic effect induced by <jats:italic>AC018926.2<\/jats:italic> overexpression. Moreover, the results of bioinformatics analysis and RNA immunoprecipitation assay suggested that <jats:italic>AC018926.2<\/jats:italic> might transcriptionally regulate <jats:italic>ITGA2<\/jats:italic> expression by binding to PARP1 protein. Our data suggest that <jats:italic>AC018926.2<\/jats:italic> may serve as a therapeutic target for the management of periodontitis in obese patients.<\/jats:p>","DOI":"10.1111\/cpr.13411","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T03:49:39Z","timestamp":1675223379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<scp>Long non\u2010coding RNA <i>AC018926<\/i><\/scp><i>.2<\/i> regulates palmitic acid exposure\u2010compromised osteogenic potential of periodontal ligament stem cells via the <scp>ITGA2<\/scp>\/<scp>FAK<\/scp>\/<scp>AKT<\/scp> pathway"],"prefix":"10.1111","volume":"56","author":[{"given":"Hong\u2010Lei","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Periodontology, State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, School of Stomatology Fourth Military Medical University  Xi'an 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