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However, the function and mechanism of circRNAs in liver fibrosis remain unknown and are the focus of this study. Murine fibrotic models were induced by thioacetamide (TAA) or carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>). Increased angiogenesis is accompanied by liver fibrosis in TAA\u2010 and CCl<jats:sub>4<\/jats:sub>\u2010induced murine fibrotic livers. circRNA microarray and argonaute 2 (AGO2)\u2010RNA immunoprecipitation (RIP) sequencing (AGO2\u2010RIP sequencing) were performed in murine livers to screen for functional circRNAs. Compared to control livers, 86 differentially expressed circRNAs were obtained in TAA\u2010induced murine fibrotic livers using circRNA microarray. In addition, 551 circRNAs were explored by AGO2\u2010RIP sequencing of murine fibrotic livers. The circRNA\u2010007371 was then selected and verified for back\u2010spliced junction, resistance to RNase R, and loop formation. In vitro, murine hemangioendothelioma endothelial (EOMA) cells were transfected with circRNA\u2010007371 overexpressing plasmid or empty plasmid. circRNA\u2010007371 overexpression promoted tube formation, migration, and cell proliferation of EOMA cells. RNA sequencing and miRNA sequencing were then performed to explore the mechanism of the proangiogenic effects of circRNA\u2010007371. circRNA\u2010007371 promotes liver fibrosis via miRNA sponges or ceRNA mechanisms. <jats:italic>Stag1<\/jats:italic>, the parent gene of circRNA\u2010007371, may play a significant role in proangiogenic progression. In conclusion, circRNA\u2010007371 enhances angiogenesis via a miRNA sponge mechanism in liver fibrosis. The antiangiogenic effect of circRNA\u2010007371 inhibition may provide a new strategy for treating patients with liver cirrhosis.<\/jats:p>","DOI":"10.1111\/cpr.13432","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T04:20:27Z","timestamp":1677644427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Proangiogenic role of <scp>circRNA<\/scp>\u2010007371 in liver fibrosis"],"prefix":"10.1111","volume":"56","author":[{"given":"Chong","family":"Zhao","sequence":"first","affiliation":[{"name":"Lab of Gastroenterology and Hepatology West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Gastroenterology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaijie","family":"Qian","sequence":"additional","affiliation":[{"name":"Lab of Gastroenterology and Hepatology West China Hospital, 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