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The clinical management of liver metastases is challenging because of their strong heterogeneity, rapid progression, and poor prognosis. Now, exosomes, small membrane vesicles that are 40\u2013160\u2009nm in size, are released by tumour cells, namely, tumour\u2010derived exosomes (TDEs), and are being increasingly studied because they can retain the original characteristics of tumour cells. Cell\u2013cell communication via TDEs is pivotal for liver pre\u2010metastatic niche (PMN) formation and liver metastasis; thus, TDEs can provide a theoretical basis to intensively study the potential mechanisms of liver metastasis and new insights into the diagnosis and treatment of liver metastasis. Here, we systematically review current research progress about the roles and possible regulatory mechanisms of TDE cargos in liver metastasis, focusing on the functions of TDEs in liver PMN formation. In addition, we discuss the clinical utility of TDEs in liver metastasis, including TDEs as potential biomarkers, and therapeutic approaches for future research reference in this field.<\/jats:p>","DOI":"10.1111\/cpr.13452","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:54:06Z","timestamp":1679360046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Tumour\u2010derived exosomes in liver metastasis: A Pandora's box"],"prefix":"10.1111","volume":"56","author":[{"given":"Sini","family":"Li","sequence":"first","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qu","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical 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