{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:58:12Z","timestamp":1789588692062,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2202YFC2502800"],"award-info":[{"award-number":["2202YFC2502800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Age\u2010related macular degeneration (AMD) and diabetic retinopathy (DR) are the world's leading causes of blindness. The retinal pigment epithelium (RPE) and vascular endothelial cell exposed to oxidative stress is the major cause of AMD and DR. DJ\u20101, an important endogenous antioxidant, its overexpression is considered as a promising antioxidant treatment for AMD and DR. Here, we modified the tetrahedral frame nucleic acids (tFNAs) with DJ\u20101 saRNAs as a delivery system, and synthesized a novel nanocomplex (tFNAs\u2010DJ\u20101 saRNAs). In vitro studies show that tFNAs\u2010DJ\u20101 saRNAs can efficiently transfer DJ\u20101 saRNAs to human umbilical vein endothelial cells (HUVECs) and ARPE\u201019s, and significantly increased their cellular DJ\u20101 level. Reactive oxygen species expression in H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010treated HUVECs and ARPE\u201019s were decreased, cell viability was enhanced and cell apoptosis were inhibited when tFNAs\u2010DJ\u20101 saRNAs were delivered. Moreover, tFNAs\u2010DJ\u20101 saRNAs preserved mitochondrial structure and function under oxidative stress conditions. In the aspect of molecular mechanism, tFNAs\u2010DJ\u20101 saRNAs activated Erk and Nrf2 pathway, which might contribute to its protective effects against oxidative stress damage. To conclude, this study shows the successfully establishment of a simple but effective delivery system of DJ\u20101 saRNAs associated with antioxidant effects in AMD and DR, which may be a promising agent for future treatment in oxidative stress\u2010related retinal disorders.\n                  <\/jats:p>","DOI":"10.1111\/cpr.13635","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T02:14:40Z","timestamp":1712715280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The antioxidant effect of tetrahedral framework nucleic acid\u2010based delivery of small activating RNA targeting DJ\u20101 on retinal oxidative stress injury"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3054-2682","authenticated-orcid":false,"given":"Qiaowei","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology General Hospital of Central Theater Command  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology General Hospital of Central Theater Command  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianggui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology General Hospital of Central Theater Command  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delun","family":"Luo","sequence":"additional","affiliation":[{"name":"Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu 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