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The causative factors, pathogenesis, and characteristics of common CVD differ, but they all involve common pathological processes such as inflammation, oxidative stress, and fibrosis. S100A9 belongs to the S100 family of calcium\u2010binding proteins, which are mainly secreted by myeloid cells and bind to the Toll\u2010like receptor 4 and receptor for advanced glycation end products and is involved in regulating pathological processes such as inflammatory response, fibrosis, vascular calcification, and endothelial barrier function in CVD. The latest research has found that S100A9 is a key biomarker for diagnosing and predicting various CVD. Therefore, this article reviews the latest research progress on the diagnostic and predictive, and therapeutic value of S100A9 in inflammatory\u2010related CVD such as atherosclerosis, myocardial infarction, and arterial aneurysm and summarizes its molecular mechanisms in the progression of CVD, aiming to explore new predictive methods and to identify potential intervention targets for CVD in clinical practice.<\/jats:p>","DOI":"10.1111\/cpr.13636","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T05:39:18Z","timestamp":1710913158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Advances in the study of <scp>S100A9<\/scp> in cardiovascular diseases"],"prefix":"10.1111","volume":"57","author":[{"given":"Fengling","family":"Chen","sequence":"first","affiliation":[{"name":"Hengyang Medical School University of South China  Hengyang Hunan China"},{"name":"Department of Cardiovascular Medicine, Zhuzhou Hospital Affiliated to Xiangya School of Medicine Central South University  Zhuzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Zhuzhou Hospital Affiliated to Xiangya School of Medicine Central South University  Zhuzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Zhuzhou Hospital Affiliated to Xiangya School of Medicine Central South University  Zhuzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Si","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of Technology  Zhuzhou 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