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At present, the existing treatment options are mostly aimed at relieving symptoms, but the long\u2010term efficacy is not ideal. Tetrahedral framework nucleic acids (tFNAs) are regarded as a type of nanomaterial with excellent biosafety and prominent performance in anti\u2010apoptosis and anti\u2010inflammation. MicroRNA155 is a non\u2010coding RNA involved in various biological processes such as cell proliferation and apoptosis. In this study, a complex named TR155 was designed and synthesised with microRNA155 attached to the vertex of tFNAs, and its effects on the nucleus pulposus cells of intervertebral discs were evaluated both in vitro and in vivo. The experimental results showed that TR155 was able to alleviate the degeneration of intervertebral disc tissue and inhibit nucleus pulposus cell apoptosis via Bcl\u20102\/Bax pathway, indicating its potential to be a promising option for the treatment of IDD.<\/jats:p>","DOI":"10.1111\/cpr.13689","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T09:59:39Z","timestamp":1718877579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Tetrahedral framework nucleic acids\u2010based delivery of <scp>microRNA<\/scp>\u2010155 alleviates intervertebral disc degeneration through targeting Bcl\u20102\/Bax apoptosis pathway"],"prefix":"10.1111","volume":"57","author":[{"given":"Zhuhai","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of 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