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These cells, pivotal in innate immunity, offer a rapid and potent response against cancer cells and pathogens without the need for prior sensitization or recognition of peptide antigens. Although NK cell genetic modification is evolving, the viral transduction method continues to be inefficient and fraught with risks, often resulting in cytotoxic outcomes and the possibility of insertional mutagenesis. Consequently, there has been a surge in the development of non\u2010viral transfection technologies to overcome these challenges in NK cell engineering. Non\u2010viral approaches for CAR\u2010NK cell generation are becoming increasingly essential. 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