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Research on both human and animal models have highlighted the therapeutic potential of targeting the LC\u2010NE system to mitigate the progression of ND and alleviate associated psychiatric symptoms. However, the early and widespread degeneration of the LC\u2010NE system presents a significant challenge for direct intervention in ND. Recent advances in regenerative cell therapy offer promising new strategies for ND treatment. The regeneration of LC\u2010NE from pluripotent stem cells (PSCs) could significantly broaden the scope of LC\u2010NE\u2010based therapies for ND. In this review, we delve into the fundamental background and physiological functions of LC\u2010NE. Additionally, we systematically examine the evidence and role of the LC\u2010NE system in the neuropathology of ND and psychiatric diseases over recent years. Notably, we focus on the significance of PSCs\u2010derived LC\u2010NE and its potential impact on ND therapy. A deeper understanding and further investigation into the regeneration of LC\u2010NE function could pave the way for practical and effective treatments for ND.<\/jats:p>","DOI":"10.1111\/cpr.13807","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T06:20:08Z","timestamp":1738131608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Regenerating Locus Coeruleus\u2010Norepinephrine (<scp>LC<\/scp>\u2010<scp>NE<\/scp>) Function: A Novel Approach for Neurodegenerative Diseases"],"prefix":"10.1111","volume":"58","author":[{"given":"Yana","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC) Nanjing University  Nanjing 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