{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:33Z","timestamp":1787014053861,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371624"],"award-info":[{"award-number":["82371624"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3600304"],"award-info":[{"award-number":["2022YFC3600304"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2704700"],"award-info":[{"award-number":["2022YFC2704700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The lack of accurate understanding of cellular physiology and pathophysiology during the WOI constitutes the major obstacle to correct diagnosis and treatment for patients with recurrent implantation failure (RIF). The role of cilia as one of the key organelles in endometrial epithelium has been poorly understood during embryo implantation. In this study, the morphological and molecular changes of endometrial cilia regulated by hormones were demonstrated in endometrial epithelial organoid models. Multi\u2010omics studies revealed highly relevant cilia\u2010related activities like cilia movement during endometrial receptivity establishment. Interestingly, both in\u00a0vitro model and in\u00a0vivo patient data have shown that the apical part of cilium formed a cilia\u2010derived spherical structure after hormone stimulation. We also found intraflagellar transport (IFT) train multi\u2010subunit complex B (IFT\u2010B) was aggregated in the sphere during the implantation window. Meanwhile mitochondria localization signal increased at the cilia basement. Proteomics and the functional assay showed the deficiency of energy metabolism in RIF patients and cilia formation abnormalities. The abnormal energy supply resulted in the failure of vesicle transport by deficiency of IFT\u2010B location, ultimately leading to the failure of receptivity establishment. Our study revealed the essential role of endometrial cilia in embryo implantation and indicated that mitochondrial metabolism was crucial for normal ciliogenesis and embryo implantation.<\/jats:p>","DOI":"10.1111\/cpr.13819","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T22:50:31Z","timestamp":1738882231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ciliary\n                    <scp>IFT<\/scp>\n                    \u2010B Transportation Plays an Important Role in Human Endometrial Receptivity Establishment and is Disrupted in Recurrent Implantation Failure Patients"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2463-0766","authenticated-orcid":false,"given":"Haoxuan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Joint Laboratory of Reproductive Medicine (SCU\u2010CUHK) West China Second University Hospital of Sichuan University  Chengdu P. 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Godollo Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuzhi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Sichuan Provincial Maternity and Child Health Care Hospital  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Sichuan Provincial Maternity and Child Health Care Hospital  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Chiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese University of Hong Kong\u2010Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong Kong  Hong Kong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University, Ministry of Education  Chengdu P. R. China"},{"name":"Department of Gynecology and Obstetrics West China Second University Hospital of Sichuan University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou P. R. 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