{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:47:04Z","timestamp":1793148424393,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502800"],"award-info":[{"award-number":["2022YFC2502800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Retinal ischaemia\/reperfusion injury (RI\/RI) is the primary pathophysiological mechanism underlying retinal ischaemic diseases, potentially resulting in significant and irreversible visual impairment. Currently, there are no effective treatments available for RI\/RI, and oxidative stress is a critical factor that contributes to the associated damage. DJ\u20101, an important endogenous antioxidant, has been proposed as a promising therapeutic agent for RI\/RI owing to its potential for overexpression. In this study, tetrahedral frame nucleic acids (tFNAs) were utilised as an effective delivery vehicle for DJ\u20101 small activating RNA (saRNA), resulting in the synthesis of a novel nanocomposite (tFNAs\u2010DJ\u20101\u2010saRNA). In\u00a0vitro experiments demonstrated that tFNAs effectively delivered DJ\u20101\u2010saRNA to R28 cells, thus exerting a repair effect on oxidative stress injury. In\u00a0vivo investigations revealed that the intravitreal injection of tFNAs\u2010DJ\u20101\u2010saRNA facilitated retinal DJ\u20101 gene expression and mitigated retinal atrophy induced by RI\/RI. Mechanistically, tFNAs\u2010DJ\u20101\u2010saRNA activated the xCT\/GPX4 pathway, thereby inhibiting ferroptosis, reducing ganglion cell damage and protecting the retinal tissue. In conclusion, this study demonstrated that the tFNAs\u2010DJ\u20101\u2010saRNA complex can ameliorate RI\/RI by inhibiting ferroptosis, suggesting its potential as a novel agent for the treatment of retinal ischaemic diseases.<\/jats:p>","DOI":"10.1111\/cpr.13820","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:40:24Z","timestamp":1740098424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tetrahedral Framework Nucleic Acid\u2010Based Delivery of <scp>DJ<\/scp>\u20101\u2010<scp>saRNA<\/scp> Prevent Retinal Ischaemia\u2013Reperfusion Injury via Inhibiting Ferroptosis"],"prefix":"10.1111","volume":"58","author":[{"given":"Xianggui","family":"Zhang","sequence":"first","affiliation":[{"name":"The First School of Clinical Medical Southern Medical University  Guangzhou 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