{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:18:37Z","timestamp":1790093917746,"version":"4.0.1"},"reference-count":74,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","award":["CARS\u201039\u201007"],"award-info":[{"award-number":["CARS\u201039\u201007"]}],"id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The intricate mechanisms driving oocyte maturation remain only partially understood, especially within the domains of domestic animal reproduction and translational medicine. In the case of prepubertal girls, the clinical challenge is especially pronounced, as ovarian tissue cryopreservation\u2010though promising\u2010remains an experimental technique necessitating rigorous scientific validation to guarantee the developmental potential of preserved materials and facilitate broader clinical adoption. To address these knowledge gaps, while considering the ethical implications, we applied transcriptome and translatome sequencing to comprehensively profile the transcriptional and translational dynamics of oocyte maturation in adult and prepubertal goats. Our analyses uncovered a sequential transition in gene expression regulation, shifting from cytoplasmic processes to chromosome segregation during the maturation process. Comparative profiling between adult and prepubertal goat oocytes revealed critical regulatory factors essential for prepubertal oocyte maturation. These include genes involved in organelle function (\n                    <jats:italic>GTPBP4<\/jats:italic>\n                    and\n                    <jats:italic>TOMM7<\/jats:italic>\n                    ), spindle organisation (\n                    <jats:italic>CKS2<\/jats:italic>\n                    ,\n                    <jats:italic>CCP110<\/jats:italic>\n                    ,\n                    <jats:italic>CKAP5<\/jats:italic>\n                    and\n                    <jats:italic>ESCO1<\/jats:italic>\n                    ) and chromosome segregation (\n                    <jats:italic>CENPE<\/jats:italic>\n                    ,\n                    <jats:italic>CENPF<\/jats:italic>\n                    ,\n                    <jats:italic>CENPN<\/jats:italic>\n                    and\n                    <jats:italic>SGO2<\/jats:italic>\n                    ). Functional validation through in\u00a0vitro maturation experiments demonstrated that GTPBP4 significantly enhances the developmental competence of prepubertal goat oocytes. This enhancement occurs through mechanisms that promote cell cycle progression, organelle maturation and mRNA translation. These findings provide a detailed map of the molecular events underpinning goat oocyte maturation and offer new perspectives on the developmental strategies required for oocyte competence in prepubertal females. Translating these insights to humans, this research highlights potential fertility preservation strategies for prepubertal girls, such as ovarian tissue cryopreservation and transplantation, in\u00a0vitro follicle culture, meiotic maturation and artificial ovary technologies. Moreover, the identified mechanisms have significant implications for improving reproductive efficiency in domestic animal breeding, bridging basic research and applied science.\n                  <\/jats:p>","DOI":"10.1111\/cpr.70017","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:23:59Z","timestamp":1741742639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Decoding the Molecular Landscape of Prepubertal Oocyte Maturation:\n                    <scp>GTPBP4<\/scp>\n                    as a Key Driver of In\u00a0Vitro Developmental Competence"],"prefix":"10.1111","volume":"58","author":[{"given":"Jianpeng","family":"Qin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology Sichuan Agricultural University Sichuan  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozong","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology Sichuan Agricultural University Sichuan  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Ning","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology Sichuan Agricultural University Sichuan  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Hu","sequence":"additional","affiliation":[{"name":"California Institute of Technology  Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Wan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Sheep Genetic Improvement and Healthy Breeding, Institute of Animal Husbandry and Veterinary Sciences Xinjiang Academy of Agricultural and Reclamation Sciences  Shihezi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beijia","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key 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Animal Science and Technology Sichuan Agricultural University Sichuan  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunlin","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology Sichuan Agricultural University Sichuan  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology Sichuan Agricultural University Sichuan  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology Sichuan Agricultural University Sichuan  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology Sichuan Agricultural University Sichuan  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqin","family":"Zang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology Sichuan Agricultural University Sichuan  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangfeng","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology Sichuan Agricultural University Sichuan  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhi","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Life Science Sichuan Agricultural University  Ya'an Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxia","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Life Science Sichuan Agricultural University  Ya'an Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuhong","family":"Shen","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Animal Disease and Human Health of Sichuan Province, The Medical Research Center for Cow Disease, College of Veterinary Medicine Sichuan Agricultural University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chengdu Xiling Snow Agricultural Development Co., LTD  Chengdu Sichuan 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