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Nonetheless, emerging research indicates a significant association between the N6\u2010methyladenosine (m6A) methylase METTL3 and osteogenesis in OP. To investigate Mettl3's impact on osteogenic potential and the underlying molecular mechanisms, an OP rat model was established via ovariectomy (OVX). Osteoporotic adipose\u2010derived stem cells (OP\u2010ASCs) were then isolated. Results indicated a significant downregulation of Mettl3 expression in OP\u2010ASCs. Subsequently, OP\u2010ASCs were transfected with overexpressed Mettl3 lentivirus and treated for Dickkopf\u2010related protein\u20101 (DKK1). Overexpression of the Mettl3 gene led to increased levels of osteogenic factors. DKK1 attenuated osteoblastic differentiation capacity in the Mettl3 overexpression group by inhibiting the Wnt signalling pathway. Consistent results were observed in\u00a0vivo experiments. 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