{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:59:16Z","timestamp":1792195156154,"version":"4.4.0"},"reference-count":293,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Colorectal cancer (CRC) is one of the most common malignant tumours and is the second leading cause of cancer\u2010related mortality worldwide. Despite the availability of preventative, diagnostic and treatment methods including endoscopic treatment, surgical intervention, radiotherapy, biologics, salvage therapy and immunotherapy, the mortality rate associated with CRC remains alarming. Consequently, there is a pressing need to search for medicines for the treatment of CRC. Phytomedicines have been shown to suppress the proliferation and metastasis of CRC through various mechanisms, including immune regulation, modulation of gut microbiota, targeting of stem cells, macrophage polarisation, glycolysis, ferroptosis induction, modulation of extracellular vesicles, activation of mitochondria\u2010induced apoptosis, inflammation reduction, oxidative stress management and intervention of autophagy. Furthermore, numerous studies have reported the anti\u2010cancer and anti\u2010metastatic effects of various phytomedicines, including curcumin, resveratrol, berberine, shikonin, dihydroartemisinin, fucoidan, luteolin, andrographolide, piperine, kaempferol, emodin, cannabidiol, tanshinone IIA and evodiamine. In this review, we sort out the effects and mechanisms of phytomedicines on CRC and outline the major phytomedicines commonly used in CRC treatment. We hope that these phytomedicines may serve as promising drugs or important lead compounds for the management of CRC.<\/jats:p>","DOI":"10.1111\/cpr.70065","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T07:24:51Z","timestamp":1749453891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7872-6229","authenticated-orcid":false,"given":"Zuqing","family":"Su","sequence":"first","affiliation":[{"name":"State Key Laboratory of Traditional Chinese Medicine Syndrome The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong\u2010Hong Kong\u2010Macau Joint Lab on Chinese Medicine and Immune Disease Research The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Traditional Chinese Medicine Syndrome The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong\u2010Hong Kong\u2010Macau Joint Lab on Chinese Medicine and Immune Disease Research The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Traditional Chinese Medicine Syndrome The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong\u2010Hong Kong\u2010Macau Joint Lab on Chinese Medicine and Immune Disease Research The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Feng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong\u2010Hong Kong\u2010Macau Joint Lab on Chinese Medicine and Immune Disease Research The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Traditional Chinese Medicine Syndrome The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong\u2010Hong Kong\u2010Macau Joint Lab on Chinese Medicine and Immune Disease Research The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5570-2470","authenticated-orcid":false,"given":"Guangjuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong\u2010Hong Kong\u2010Macau Joint Lab on Chinese Medicine and Immune Disease Research The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00426-X"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14122928"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-023-10158-3"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32319-0"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2023.103669"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-023-00719-7"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010073"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.10"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118260"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154076"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154454"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01206-X"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155370"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1238694"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347354211017219"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-021-00453-y"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154900"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106121"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.03.065"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1638-6"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06299-8"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-024-00859-1"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.08.014"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16050981"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305089"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.72509"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0932-y"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c01183"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117399"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117069"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X23500714"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113399"},{"issue":"2","key":"e_1_2_13_35_1","first-page":"225","article-title":"Ginseng Berry Concentrate Prevents Colon Cancer via Cell Cycle, Apoptosis Regulation, and Inflammation\u2010Linked Th17 Cell Differentiation","volume":"72","author":"Wang C. Z.","year":"2021","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-07079-1"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500605"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2023.11.008"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102021\u2010002591"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-329543"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2022.100886"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00596-9"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153917"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735419846377"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154898"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00766-x"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-025-01683-9"},{"issue":"10","key":"e_1_2_13_48_1","first-page":"291","article-title":"Effect of Cyasterone on Intestinal Flora in a (BRAF)V600E\u2010Mutant Mouse Model of Colorectal Cancer","volume":"77","author":"Xiong Y.","year":"2022","journal-title":"Die Pharmazie"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001692"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119715"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110916"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153606"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.153966"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154227"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092298"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117292"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.81824"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09635-9"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154217"},{"key":"e_1_2_13_60_1","first-page":"11","article-title":"A Holistic View of Berberine Inhibiting Intestinal Carcinogenesis in Conventional Mice Based on Microbiome\u2010Metabolomics Analysis","volume":"2020","author":"Chen H.","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-023-04836-7"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34528"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14040726"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24405"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155385"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02913-0"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03733-5"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.02.022"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114270"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154234"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1760"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4378"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119447"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153493"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6183"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0421-3"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153191"},{"issue":"1","key":"e_1_2_13_78_1","first-page":"127","article-title":"Ginsenoside Rg3 Targets Cancer Stem Cells and Tumor Angiogenesis to Inhibit Colorectal Cancer Progression In\u00a0Vivo","volume":"52","author":"Tang Y. C.","year":"2018","journal-title":"International Journal of Oncology"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9060572"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153797"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1103617"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168470"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2016.09.011"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153489"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02108-6"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347354241247061"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2024.110051"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.111038"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155144"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112610"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00303.2021"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14330"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-024-03662-0"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114915"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217156"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.02.029"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2019.1631858"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00273"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.09.003"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.149763"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.149451"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104864"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174370"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2022.5309"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c07640"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X23500349"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2200221"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2023.04.013"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347354221138534"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203357"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103087"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI143691"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02149-6"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2023068"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-20-3094"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgad122"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14468"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16030383"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2022.2139398"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8258"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.59404"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-024-01973-2"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-024-01258-z"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.94628"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.05.008"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.09.014"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-023-04549-0"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2023.2216922"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13082751"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/life14081017"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6177553"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.12072"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00991-2"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-024-03204-7"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202102620"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108332"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154082"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.05.033"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1607672924600180"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118296"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29081793"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-024-00882-9"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26134081"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.04.142"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-018-1585-2"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.111878"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2024.2309871"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49221-0"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.50051"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2017.12.027"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118662"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.23-533"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116207"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12860-018-0174-z"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.170"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153484"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2012.10.008"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22176"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.15496"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2012.45.4.242"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04311-4"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103527"},{"issue":"3","key":"e_1_2_13_163_1","first-page":"1","article-title":"Resveratrol Induces Human Colorectal Cancer Cell Apoptosis by Activating the Mitochondrial Pathway via Increasing Reactive Oxygen Species","volume":"23","author":"Fu Y.","year":"2021","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.674340"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500719"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-023-02688-z"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7808"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-023-3698-9"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X23500118"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10895-023-03145-y"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2013.3121"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2017.09.006"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i30.4053"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.02.011"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9091043"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.55730\/1300-0144.5652"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020.1771384"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25073735"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-008-0335-2"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102008\u201005\u2010155952"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01480-2"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23645"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25451"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161126031"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2022.12704"},{"key":"e_1_2_13_186_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.797605"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-023-04254-8"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000760"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.153972"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174253"},{"key":"e_1_2_13_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154639"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.01.008"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4457"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.03.033"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.06.022"},{"key":"e_1_2_13_196_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00189"},{"key":"e_1_2_13_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172483"},{"key":"e_1_2_13_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.10.021"},{"key":"e_1_2_13_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118644"},{"key":"e_1_2_13_200_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2424-0"},{"key":"e_1_2_13_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111260"},{"key":"e_1_2_13_202_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247190"},{"key":"e_1_2_13_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.10.035"},{"key":"e_1_2_13_204_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10050743"},{"key":"e_1_2_13_205_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040901"},{"key":"e_1_2_13_206_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.367"},{"key":"e_1_2_13_207_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-06035-9"},{"key":"e_1_2_13_208_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.2006.06034"},{"key":"e_1_2_13_209_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2018.1540719"},{"key":"e_1_2_13_210_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-020-2289-7"},{"key":"e_1_2_13_211_1","doi-asserted-by":"publisher","DOI":"10.1177\/10915818221104417"},{"key":"e_1_2_13_212_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1161"},{"key":"e_1_2_13_213_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030857"},{"key":"e_1_2_13_214_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b04472"},{"key":"e_1_2_13_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.153932"},{"key":"e_1_2_13_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.05.026"},{"key":"e_1_2_13_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153414"},{"key":"e_1_2_13_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.12.025"},{"key":"e_1_2_13_219_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520620666200717143109"},{"key":"e_1_2_13_220_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530319666191125111920"},{"key":"e_1_2_13_221_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2018.1470649"},{"key":"e_1_2_13_222_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020.1828942"},{"key":"e_1_2_13_223_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15393"},{"key":"e_1_2_13_224_1","doi-asserted-by":"publisher","DOI":"10.1177\/11795549211012672"},{"key":"e_1_2_13_225_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-022-01691-2"},{"key":"e_1_2_13_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.153923"},{"key":"e_1_2_13_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2016.02.015"},{"key":"e_1_2_13_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.10.148"},{"key":"e_1_2_13_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.11.101"},{"key":"e_1_2_13_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2016.01.015"},{"key":"e_1_2_13_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153306"},{"key":"e_1_2_13_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2015.11.008"},{"key":"e_1_2_13_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155116"},{"key":"e_1_2_13_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.111981"},{"key":"e_1_2_13_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112600"},{"key":"e_1_2_13_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.137393"},{"key":"e_1_2_13_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117006"},{"key":"e_1_2_13_238_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.138835"},{"key":"e_1_2_13_239_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.11999"},{"key":"e_1_2_13_240_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v7.i11.271"},{"key":"e_1_2_13_241_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-018-0031-8"},{"key":"e_1_2_13_242_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11202-3"},{"key":"e_1_2_13_243_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867329666220914112042"},{"key":"e_1_2_13_244_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1542204"},{"key":"e_1_2_13_245_1","first-page":"9","article-title":"Origanum majorana Ethanolic Extract Promotes Colorectal Cancer Cell Death by Triggering Abortive Autophagy and Activation of the Extrinsic Apoptotic Pathway","volume":"2019","author":"Benhalilou N.","year":"2019","journal-title":"Frontiers in Oncology"},{"key":"e_1_2_13_246_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10030412"},{"key":"e_1_2_13_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153809"},{"key":"e_1_2_13_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114475"},{"key":"e_1_2_13_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155174"},{"key":"e_1_2_13_250_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08336-4"},{"key":"e_1_2_13_251_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.66737"},{"key":"e_1_2_13_252_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24112102"},{"key":"e_1_2_13_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115876"},{"key":"e_1_2_13_254_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1409627"},{"key":"e_1_2_13_255_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-024-00934-z"},{"key":"e_1_2_13_256_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X24500460"},{"key":"e_1_2_13_257_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155615"},{"key":"e_1_2_13_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116915"},{"key":"e_1_2_13_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116866"},{"key":"e_1_2_13_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154567"},{"key":"e_1_2_13_261_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154772"},{"key":"e_1_2_13_262_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010022\u201000641\u20104"},{"key":"e_1_2_13_263_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1419-z"},{"key":"e_1_2_13_264_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1119-y"},{"key":"e_1_2_13_265_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153530"},{"key":"e_1_2_13_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154070"},{"key":"e_1_2_13_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112262"},{"key":"e_1_2_13_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.10.025"},{"key":"e_1_2_13_269_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.09.219"},{"key":"e_1_2_13_270_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347354231213613"},{"issue":"1","key":"e_1_2_13_271_1","first-page":"373","article-title":"Herbal Prescription, Danggui\u2010Sayuk\u2010Ga\u2010Osuyu\u2010Senggang\u2010Tang, Inhibits TNF\u2010\u03b1\u2010Induced Epithelial\u2010Mesenchymal Transition in HCT116 Colorectal Cancer Cells","volume":"41","author":"Lee K.","year":"2018","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_13_272_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-73234-9_1"},{"key":"e_1_2_13_273_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357907.2010.550592"},{"key":"e_1_2_13_274_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2014.06.010"},{"key":"e_1_2_13_275_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940\u20106207.CAPR\u201012\u20100281"},{"key":"e_1_2_13_276_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0744"},{"key":"e_1_2_13_277_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.05.005"},{"key":"e_1_2_13_278_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxz029"},{"key":"e_1_2_13_279_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201010\u20102027"},{"key":"e_1_2_13_280_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-11-0148"},{"key":"e_1_2_13_281_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30409-1"},{"key":"e_1_2_13_282_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.07.068"},{"key":"e_1_2_13_283_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347354231187153"},{"key":"e_1_2_13_284_1","doi-asserted-by":"publisher","DOI":"10.3390\/md15040122"},{"key":"e_1_2_13_285_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30141-3"},{"key":"e_1_2_13_286_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.2187"},{"key":"e_1_2_13_287_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.01.014"},{"key":"e_1_2_13_288_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-20-0598"},{"key":"e_1_2_13_289_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-021-3281-1"},{"key":"e_1_2_13_290_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-017-2962-2"},{"key":"e_1_2_13_291_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-023-04052-2"},{"key":"e_1_2_13_292_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-016-2581-3"},{"key":"e_1_2_13_293_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117853"},{"key":"e_1_2_13_294_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155496"}],"container-title":["Cell Proliferation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpr.70065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:54:32Z","timestamp":1760000072000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpr.70065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,9]]},"references-count":293,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/cpr.70065"],"URL":"https:\/\/doi.org\/10.1111\/cpr.70065","archive":["Portico"],"relation":{},"ISSN":["0960-7722","1365-2184"],"issn-type":[{"value":"0960-7722","type":"print"},{"value":"1365-2184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,9]]},"assertion":[{"value":"2025-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70065"}}