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Fetal growth restriction (FGR) is frequently associated with inadequate maternal nutrition supply and impaired placental function. The precise mechanisms linking maternal nutrient deficiency to compromised fetal and placental development remain largely elusive. In this study, we conducted an in\u2010depth analysis by integrating single\u2010cell\/single\u2010nucleus RNA sequencing data from human and mouse placentas along with transcriptomic data from FGR placenta, identifying the\n                    <jats:italic>GAB1<\/jats:italic>\n                    (GRB2\u2010associated binding protein 1) gene as a potential mediator of dysregulated maternal\u2013fetal exchange, thereby affecting fetal growth. Using a mouse model, we demonstrated that food restriction significantly impeded fetal growth and disrupted placental labyrinth development. Through an in\u00a0vitro trophoblast differentiation model, we revealed that nutritional restriction impaired GAB1 stability via LC3\u2010interacting region (LIR) motif\u2010mediated selective autophagic degradation, thereby hindering GAB1\u2010MAPK signalling\u2010enhanced trophoblast syncytialisation. These findings elucidate the mechanisms by which placental GAB1 links maternal nutrition status with fetal growth and suggest potential therapeutic strategies for managing pregnancy complications such as FGR.\n                  <\/jats:p>","DOI":"10.1111\/cpr.70069","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T20:54:02Z","timestamp":1750712042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Maternal Nutritional Status Governs Fetal Development by Modulating Imprinting Gene\n                    <scp>GAB1<\/scp>\n                    \u2010Mediated Trophoblast Differentiation in the Placenta"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4461-9106","authenticated-orcid":false,"given":"Mingming","family":"Fan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology, 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