{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:50:42Z","timestamp":1780375842305,"version":"3.54.1"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103705"],"award-info":[{"award-number":["82103705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Melasma is a recurrent and treatment\u2010resistant hyperpigmentation disorder characterized by a complex and multifactorial pathogenesis. However, the lack of a stable and reliable animal model has hindered systematic investigations into its onset and progression. In this study, we established a melasma\u2010like model in C57BL\/6J mice by combining broadband UVB irradiation, intramuscular progesterone administration, and induced emotional stress. The affected skin areas exhibited irregular, brown hyperpigmented patches. Histopathological analysis revealed an accumulation of melanin granules in the epidermis and superficial dermis, elevated levels of tyrosinase (TYR) in both skin and plasma, systemic oxidative stress imbalance, and reduced autophagic activity in the lesional skin. Furthermore, this model displayed distinct differences from a UV\u2010induced post\u2010inflammatory hyperpigmentation (PIH) model. Notably, the melasma\u2010like mice responded to tranexamic acid treatment in a manner that closely resembled clinical outcomes observed in human patients. Collectively, these findings establish a stable, reproducible, and clinically relevant mouse model of melasma, providing a valuable platform for future research into its pathogenesis and treatment.<\/jats:p>","DOI":"10.1111\/cpr.70078","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T03:35:38Z","timestamp":1752204938000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Establishment and Validation of a\n                    <scp>C57BL<\/scp>\n                    \/\n                    <scp>6J<\/scp>\n                    Mouse Model for Melasma"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7582-1845","authenticated-orcid":false,"given":"Wenzhu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Laser, Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Laser, Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyao","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Department, Hospital for Skin Diseases Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laser, Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laser, Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laser, Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laser, Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Department, Hospital for Skin Diseases Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Department, Hospital for Skin Diseases Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Lin","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Department, Hospital for Skin Diseases Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_633_18"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060824"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13059"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12684"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16542"},{"issue":"6","key":"e_1_2_10_7_1","first-page":"V10210769","article-title":"The Role of Sex Hormones in the Pathogenesis of Melasma[J]","volume":"184","author":"Goandal N. 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