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In this study, we demonstrate that homoharringtonine (HHT), an FDA\u2010approved therapeutic agent for chronic myeloid leukaemia (CML), inhibits this immune evasion by targeting the FTO\/m6A\/LILRB4 signalling pathway in monocytic AML. Utilising RNA sequencing (RNA\u2010seq) and various functional assays, we reveal that HHT treatment significantly reduces LILRB4 expression at both the RNA and protein levels, suggesting that the effects of HHT on LILRB4 are distinct from its well\u2010established role as a protein synthesis inhibitor. Mechanistically, HHT treatment markedly increases global levels of RNA m6A in THP\u20101 cells by promoting the degradation of FTO, which subsequently diminishes the expression of its downstream targets, MLL1 and LILRB4. Furthermore, in\u00a0vitro and in\u00a0vivo analyses employing monocytic AML cell lines, mouse\u2010derived AML xenograft models, and patient samples collectively support the conclusion that HHT suppresses immune evasion in monocytic AML by reducing LILRB4 expression. Importantly, the downregulation of LILRB4 resulting from HHT treatment enhances the susceptibility of THP\u20101 cells to CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell cytotoxicity, accompanied by increased markers of immune activation. Overall, our findings position HHT as a promising clinical agent for enhancing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010based cancer immunotherapy by mitigating immune evasion in monocytic AML.\n                  <\/jats:p>","DOI":"10.1111\/cpr.70090","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T06:20:21Z","timestamp":1752214821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Homoharringtonine Promotes\n                    <scp>FTO<\/scp>\n                    Degradation to Suppress\n                    <scp>LILRB4<\/scp>\n                    \u2010Mediated Immune Evasion in Acute Monocytic Leukaemia"],"prefix":"10.1111","volume":"59","author":[{"given":"Fangfang","family":"Huang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research 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