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This review explores recent developments and clinical translations of CRISPR applications in oncology, genetic and neurological disorders, infectious diseases, immunotherapy, diagnostics, and epigenome editing. CRISPR has notably progressed in oncology, where it enables the identification of novel cancer drivers, elucidation of resistance mechanisms, and improvement of immunotherapies through engineered T cells, including PD\u20101 knockout CAR\u2010T cells. Clinical trials employing CRISPR\u2010edited cells are demonstrating promising results in hematologic malignancies and solid tumours. In genetic disorders, such as hemoglobinopathies and muscular dystrophies, CRISPR\u2010Cas9 alongside advanced editors like base and prime editors show significant potential for correcting pathogenic mutations. This potential was affirmed with the FDA's first approval of a CRISPR\u2010based therapy, Casgevy, for sickle cell disease in 2023. Neurological disorders, including Alzheimer's, ALS, and Huntington's disease, are increasingly targeted by CRISPR approaches for disease modelling and potential therapeutic intervention. In infectious diseases, CRISPR\u2010based diagnostics such as SHERLOCK and DETECTR provide rapid, sensitive nucleic acid detection, particularly valuable in pathogen outbreaks like SARS\u2010CoV\u20102. Therapeutically, CRISPR systems target viral and bacterial genomes, offering novel treatment modalities. Additionally, CRISPR\u2010mediated epigenome editing enables precise regulation of gene expression, expanding therapeutic possibilities. Despite these advances, significant challenges remain, including off\u2010target effects, delivery methodologies, immune responses, and long\u2010term genomic safety concerns. Future improvements in editor precision, innovative delivery platforms, and enhanced safety assessments will be essential to fully integrate CRISPR\u2010based interventions into standard clinical practice, significantly advancing personalised medicine.<\/jats:p>","DOI":"10.1111\/cpr.70099","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T02:24:26Z","timestamp":1753064666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["<scp>CRISPR<\/scp>\n                    Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential"],"prefix":"10.1111","volume":"58","author":[{"given":"Bahareh Farasati","family":"Far","sequence":"first","affiliation":[{"name":"Research Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry Iran University of Science and Technology  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marziyeh","family":"Akbari","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Science Shahrekord University  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Amin","family":"Habibi","sequence":"additional","affiliation":[{"name":"Gene, Cell &amp; 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