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Alteration within the dual allelic variants of transcription factor TCF12 causes female infertility; however, its impact on female reproduction is still unknown. In this study, we provide evidence that TCF12 is abundantly expressed within the nucleus of oocytes during growth at the germinal vesicle (GV) stage, recognising and binding to the functional domain of target genes to moderate transcriptional activity. The absence of\n                    <jats:italic>Tcf12<\/jats:italic>\n                    in oocytes during the primordial follicular phase causes female sterility.\n                    <jats:italic>Tcf12<\/jats:italic>\n                    does not participate in meiotic maturation; however, unlike\n                    <jats:italic>Tcf3<\/jats:italic>\n                    , it is essential for fertilisation and preimplantation development.\n                    <jats:italic>Tcf12<\/jats:italic>\n                    maintains fertilisation competence by controlling the proper expression and location of cortical granules and protease ovastacin (encoded by\n                    <jats:italic>Astl<\/jats:italic>\n                    ). In contrast, zygotes without TCF12 have a prolonged mitotic cell cycle upon a decrease in protein phosphatase 2A (PP2A) activity inhibition, resulting in zygotic genome activation (ZGA) failure during the 2\u2010cell stage. Maternal knockout embryos gradually lose their developmental potential in subsequent developmental processes. These observations indicate that the maternal effect induced by\n                    <jats:italic>Tcf12<\/jats:italic>\n                    ensures preimplantation development.\n                  <\/jats:p>","DOI":"10.1111\/cpr.70110","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T04:39:53Z","timestamp":1754282393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcription Factor\n                    <scp>TCF12<\/scp>\n                    \u2010Mediated Maternal Gene Expressions in Mouse Oocyte Are Prerequisites of Successful Fertilisation and Zygotic Genome Activation"],"prefix":"10.1111","volume":"59","author":[{"given":"Lan\u2010Rui","family":"Cao","sequence":"first","affiliation":[{"name":"Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Life Sciences Institute Zhejiang University  Hangzhou China"},{"name":"Zhejiang University Medical School  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuo\u2010Qi","family":"Deng","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Life Sciences Institute Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010xin","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine Nanjing Medical University  Nanjing 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