{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:52:05Z","timestamp":1777945925208,"version":"3.51.4"},"reference-count":84,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001852","name":"Indo-French Centre for the Promotion of Advanced Research","doi-asserted-by":"publisher","award":["6503\u2010J"],"award-info":[{"award-number":["6503\u2010J"]}],"id":[{"id":"10.13039\/501100001852","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DBT\u2010RA\/2023\/July\/N\/4351"],"award-info":[{"award-number":["DBT\u2010RA\/2023\/July\/N\/4351"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["PDF\/2019\/001148"],"award-info":[{"award-number":["PDF\/2019\/001148"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Regeneration of the central nervous system (CNS) is a complex and tightly regulated process, yet the precise molecular players and transcriptional regulators involved remain incompletely understood. Here, we identify Host Cell Factor\u20101 (Hcfc1), a transcriptional co\u2010regulator, and\n                    <jats:italic>O<\/jats:italic>\n                    \u2010GlcNAc transferase (Ogt), which cleaves and\n                    <jats:italic>O<\/jats:italic>\n                    \u2010GlcNAcylates HCF\u20101, as crucial regulators of zebrafish brain and retinal regeneration. We uncover their interplay with the Hippo\/Yap signalling pathway, a well\u2010known regulator of tissue growth and repair. Knockdown of\n                    <jats:italic>hcfc1a\/b<\/jats:italic>\n                    or Ogt activity inhibition disrupts regeneration and reduces Yap levels, while Yap inhibition alone also impairs regeneration. Strikingly, overexpression of constitutively active Yap5SA rescues proliferation defects caused by Hcfc1 depletion and Ogt inhibition in retinal regeneration. Further,\n                    <jats:italic>yap1<\/jats:italic>\n                    knockdown reduces\n                    <jats:italic>hcfc1a\/b<\/jats:italic>\n                    levels, suggesting potential feedback regulation. These findings reveal a previously unrecognised regulatory axis involving Hcfc1, Ogt, and the Hippo\/Yap pathway, which governs CNS regeneration. Targeting this pathway could offer a strategy for enhancing CNS regeneration.\n                  <\/jats:p>","DOI":"10.1111\/cpr.70132","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T03:59:55Z","timestamp":1760759995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hcfc1 and Ogt Mediate Zebrafish\n                    <scp>CNS<\/scp>\n                    Regeneration Through Hippo\/Yap Signalling"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8437-0694","authenticated-orcid":false,"given":"Priyanka P.","family":"Srivastava","sequence":"first","affiliation":[{"name":"Kusuma School of Biological Sciences, Indian Institute of Technology Delhi (IITD)  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidharth","family":"Bhasin","sequence":"additional","affiliation":[{"name":"Kusuma School of Biological Sciences, Indian Institute of Technology Delhi (IITD)  New Delhi India"},{"name":"Center for Regenerative Therapies Dresden (CRTD), Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research  Mohali India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omkar Mahadeo","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research  Mohali India"},{"name":"Model Systems for Infection and Immunity (MSYS) Helmholtz Centre for Infection Research  Braunschweig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9620-2018","authenticated-orcid":false,"given":"Kshitiz","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research  Mohali India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Ayushma","sequence":"additional","affiliation":[{"name":"Kusuma School of Biological Sciences, Indian Institute of Technology Delhi (IITD)  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Medical Elementology and Toxicology Jamia Hamdard University  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6318-6506","authenticated-orcid":false,"given":"Suhel","family":"Parvez","sequence":"additional","affiliation":[{"name":"Department of Medical Elementology and Toxicology Jamia Hamdard University  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research  Mohali India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpi","family":"Minocha","sequence":"additional","affiliation":[{"name":"Kusuma School of Biological Sciences, Indian Institute of Technology Delhi (IITD)  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00427\u2010012\u20100425\u20105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1460\u20109568.2011.07833.X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/DEV.122796"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/JEB.226357\/258585"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PRETEYERES.2009.07.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.647859"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12035\u2010015\u20109428\u20103"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/CNE.901240303"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/3305"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5460.2032"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.0401596101\/SUPPL_FILE\/01596FIG7.JPG"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/CNE.21860"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20104835(78)90089\u20101"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1098\/RSTB.2006.2015"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.072587"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1228773\/SUPPL_FILE\/KYRITSIS.SM.PDF"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","unstructured":"R.Schmidt T.Beil U.Str\u00e4hle andS.Rastegar \u201cStab Wound Injury of the Zebrafish Adult Telencephalon: A Method to Investigate Vertebrate Brain Neurogenesis and Regeneration \u201d90 no.90(2014):51753 https:\/\/doi.org\/10.3791\/51753.","DOI":"10.3791\/51753"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.03.040"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.007336"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v12.i1.8"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRN3723"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/DVDY.22710"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0332\u201006.2006"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/CNE.22448"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PRETEYERES.2004.01.001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24851"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12111"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.YDBIO.2006.03.023"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/CNE.23065"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00525"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23849"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521\u20101878(200008)22:8<685::AID\u2010BIES1>3.0.CO;2\u2010C"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2018.00110"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M303470200"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.AJHG.2012.08.011"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv083"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968\u20100004(03)00088\u20104"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/EMBOJ.2009.258\/SUPPL_FILE\/EMBJ2009258\u2010SUP\u20100002.PDF"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.4161\/TRNS.20711"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2008.05.047"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2010.12.030"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg242"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136636"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1013822108\/\u2010\/DCSUPPLEMENTAL\/PNAS.1013822108_SI.PDF"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.004185"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1101\/GR.150078.112"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.07.022"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1101\/GAD.1935210"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22704"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12868\u2010020\u201000577\u20101\/FIGURES\/10"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.YDBIO.2014.09.026"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx157"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/BIOMETHODS\/BPAE073"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.GENE.2023.147290"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BCP.2024.116244"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.YDBIO.2016.02.019"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.YDBIO.2016.08.008"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.5b00004"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/JACS.8B07328"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201013\u20100549"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELREP.2017.07.017"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20180717"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536\u2010022\u201000209\u20108"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBRC.2009.04.070"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.7150\/IJBS.4887"},{"issue":"1","key":"e_1_2_9_67_1","first-page":"27","article-title":"Verteporfin Inhibits YAP Function Through Up\u2010Regulating 14\u20103\u20103\u03c3 Sequestering YAP in the Cytoplasm","volume":"6","author":"Wang C.","year":"2015","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1602907"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CMET.2012.07.006"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MOLCEL.2019.05.019"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SEMCDB.2010.05.001"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.50163"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536\u2010021\u201000163\u2010x"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.202008"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2015.10.044"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHARMR.2024.100031"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010018\u20100086\u2010y"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MOLCEL.2017.10.010"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELREP.2024.113926"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.18103\/MRA.V8I6.2122"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41598\u2010025\u201011813\u20101"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.LFS.2022.120338"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12035\u2010020\u201001924\u20103\/FIGURES\/10"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2281\u201004.2004"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.21769\/BIOPROTOC.3466"}],"container-title":["Cell Proliferation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpr.70132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cpr.70132","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpr.70132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:47:17Z","timestamp":1777729637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpr.70132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":84,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/cpr.70132"],"URL":"https:\/\/doi.org\/10.1111\/cpr.70132","archive":["Portico"],"relation":{},"ISSN":["0960-7722","1365-2184"],"issn-type":[{"value":"0960-7722","type":"print"},{"value":"1365-2184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]},"assertion":[{"value":"2025-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70132"}}