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Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy is constrained by the hostile post\u2010injury microenvironment. Here, we employed untargeted metabolomics to investigate metabolic reprogramming induced by NSC\u2010loaded multichannel collagen scaffolds in a rat SCI model. NSC transplantation significantly enhanced functional recovery and structural remodelling, concomitant with elevated neurogenesis and attenuated gliosis. Metabolomic profiling identified lysophosphatidylcholine 18:0 (LPC18:0) as a key NSC\u2010derived metabolite. Mechanistically, LPC18:0 promoted the differentiation of endogenous NSCs into neurons via the GPR55\/AKT\/GSK3\u03b2 signalling axis, as validated by receptor\u2010specific inhibition. In\u00a0vivo administration of LPC18:0 improved motor function, axonal regeneration and recruitment of immature neurons. These findings reveal a novel metabolic mechanism underlying NSC\u2010based therapy, positioning LPC18:0\/GPR55\/AKT\/GSK3\u03b2 signalling as a therapeutic target for SCI recovery.<\/jats:p>","DOI":"10.1111\/cpr.70146","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:41:06Z","timestamp":1763340066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>LPC18<\/scp>\n                    :0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via\n                    <scp>GPR55<\/scp>\n                    \u2010Mediated Signalling in Spinal Cord Injury"],"prefix":"10.1111","volume":"59","author":[{"given":"Dong","family":"Chen","sequence":"first","affiliation":[{"name":"Clinical Stem Cell Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu 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