{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:34:25Z","timestamp":1790620465897,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271690"],"award-info":[{"award-number":["82271690"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574222"],"award-info":[{"award-number":["82574222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201757"],"award-info":[{"award-number":["82201757"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Recurrent implantation failure (RIF) remains a major challenge in assisted reproductive technologies, with the underlying molecular mechanisms still largely unknown. Here, we conducted proteomic profiling and analysed publicly available single\u2010cell RNA sequencing data, revealing a marked decrease in lactate dehydrogenase A (LDHA) expression in RIF cases. While traditionally considered a metabolic byproduct, it is now recognised to play a role in signalling and epigenetic regulation. Utilising human endometrial organoids, we demonstrated that lactate enhances human endometrial receptivity by promoting epithelial\u2013mesenchymal transition (EMT) and upregulating histone H3 lysine 18 lactylation (H3K18la). Further multi\u2010omics analyses identified solute carrier family 7 member 11 (\n                    <jats:italic>SLC7A11<\/jats:italic>\n                    ) as an H3K18la\u2010regulated target. Functional assays confirmed that lactate\u2010induced H3K18la upregulates\n                    <jats:italic>SLC7A11<\/jats:italic>\n                    , thereby driving EMT and cellular migration. Notably, using a blastoid\u2013endometrial cell implantation model, we demonstrated that SLC7A11 promotes both blastoid adhesion and expansion, highlighting its critical role in embryo\u2013endometrial interactions. Collectively, leveraging multiple organoid systems, including endometrial organoids and blastoid\u2013endometrial cell implantation models, our findings reveal a novel lactate\u2013H3K18la\u2013SLC7A11 axis that orchestrates endometrial epithelial plasticity and receptivity. In addition, this study established a robust methodological framework for investigating implantation mechanisms.\n                  <\/jats:p>","DOI":"10.1111\/cpr.70147","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T01:15:01Z","timestamp":1763342101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mechanistic Insights Into Recurrent Implantation Failure: The Lactate\u2013\n                    <scp>H3K18la<\/scp>\n                    \u2013\n                    <scp>SLC7A11<\/scp>\n                    Axis Explored via Endometrial Organoid and Blastoid\u2013Endometrial Cell Implantation Models"],"prefix":"10.1111","volume":"59","author":[{"given":"Lingling","family":"Dong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"An","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Women's Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Institute  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingmin","family":"Hu","sequence":"additional","affiliation":[{"name":"Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center Nanjing Medical University  Changzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Women's Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Institute  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqian","family":"Chang","sequence":"additional","affiliation":[{"name":"Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center Nanjing Medical University  Changzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2595-0697","authenticated-orcid":false,"given":"Ruizhe","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Zhongda Hospital, School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9887-7921","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Jiangsu Environmental Health Risk Assessment Engineering Research Center, Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Innovation Center of Suzhou Nanjing Medical University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7285-0739","authenticated-orcid":false,"given":"Shuxian","family":"Wang","sequence":"additional","affiliation":[{"name":"Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center Nanjing Medical University  Changzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy044"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.74053"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13819"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew064"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaf042"},{"issue":"5","key":"e_1_2_9_7_1","first-page":"lnae036","article-title":"Integrated Transcriptomic 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