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Disruption of imprinting leads to various developmental disorders and cancers, yet our understanding of the full repertoire of imprinted genes in humans remains incomplete. Here, we utilised androgenetic, parthenogenetic and biparental human embryonic stem cells and their neural derivatives to identify novel imprinted genes by analysing their methylome and transcriptome profiles. Our analysis revealed 12 novel putative imprinted genes distributed across four distinct loci, with six of them clustered in an uncharacterised imprinted region on chromosome 19. We identified potential imprinting control regions regulating this novel cluster, suggesting a coordinated regulatory mechanism. Notably, these imprinted genes are enriched in cancer\u2010related pathways, with several showing isoform\u2010specific imprinting patterns. Our analysis also revealed consistent DNA methylation aberrations in pluripotent stem cells at specific imprinted loci, highlighting potential epigenetic instability during culturing. These findings contribute to our understanding of genomic imprinting regulation in human development and highlight potential genomic regions for further investigation of imprinting\u2010related disorders.<\/jats:p>","DOI":"10.1111\/cpr.70150","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T08:56:00Z","timestamp":1764665760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of Human Uniparental Embryonic Stem Cells Reveals New Putative Imprinted Loci"],"prefix":"10.1111","volume":"59","author":[{"given":"Shay","family":"Kinreich","sequence":"first","affiliation":[{"name":"The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics The Alexander Silberman Institute of Life Sciences, the Hebrew University of Jerusalem  Jerusalem 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