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Through analysis of stricturing intestinal tissues from CD patients and TNBS\u2010induced CD mouse models, we demonstrated that TGF\u2010\u03b21 activates the MAPK signalling pathway to induce MMT in macrophages (M\u00f8), resulting in increased expression of \u03b1\u2010SMA and collagen production. Importantly, these MMT\u2010derived myofibroblasts secrete CCL17, which recruits CCR4\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cells (Tregs) to fibrotic lesions, creating a pro\u2010fibrotic microenvironment. Further investigation showed that the adoptive transfer of M\u00f8 exacerbated fibrosis in CD mice, whilst M\u00f8 depletion attenuated this process. Therapeutically, adipose\u2010derived mesenchymal stromal cells\u2010derived extracellular vesicles (AMSC\u2010sEVs) could effectively deliver MFGE8 to inhibit MAPK activation, thereby suppressing MMT and reducing CCL17\u2010mediated Treg recruitment. Treatment with AMSC\u2010sEVs significantly improved intestinal fibrosis in CD mice, as evidenced by reduced collagen deposition and improved histological scores, whereas MFGE8 knockdown in AMSC\u2010sEVs diminished these protective effects. These findings not only establish MMT as a key mechanism driving CD\u2010associated intestinal fibrosis through the CCL17\u2010CCR4 axis but also highlight AMSC\u2010sEVs as a promising cell\u2010free therapeutic strategy targeting this pathological process.\n                  <\/jats:p>","DOI":"10.1111\/cpr.70159","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T05:14:46Z","timestamp":1767417286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>AMSC<\/scp>\n                    \u2010\n                    <scp>sEVs<\/scp>\n                    Ameliorated Crohn's Disease by Inhibiting Macrophage\u2010Myofibroblast Transition Through the Delivery of\n                    <scp>MFGE8<\/scp>"],"prefix":"10.1111","volume":"59","author":[{"given":"Minghao","family":"Xie","sequence":"first","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhong","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi 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