{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:01:08Z","timestamp":1780732868940,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Intervertebral disc degeneration (IDD) is a primary cause of low back pain, with the development of new blood vessels being a key pathological feature. Fibroblast activation protein\u2010alpha (FAP\u2010\u03b1), a member of the Type II serine protease family, possesses dipeptidase and collagenase activities and is closely linked to angiogenesis. Bioinformatics and immunohistochemical analysis revealed elevated FAP\u2010\u03b1 expression and increased angiogenesis in degenerated cartilage endplate (CEP). Co\u2010culture of FAP\u2010\u03b1\u2010silenced CEP cells or conditioned media with human umbilical vein endothelial cells (HUVECs) demonstrated a reduction in hypoxia\u2010inducible factor\u2010\u03b1 (HIF\u2010\u03b1) levels, vascular endothelial growth factor (VEGF)\u2010A and PI3K\/AKT phosphorylation, which impaired HUVEC migration and tube formation. Conversely, FAP\u2010\u03b1 overexpression enhanced angiogenesis via the PI3K\/AKT\/HIF\u2010\u03b1\/VEGF\u2010A signalling pathway. In rats with IDD induced by lumbar instability, FAP\u2010\u03b1 inhibitors reduced angiogenesis and ossification of the CEP, thereby delaying IDD progression associated with CEP degeneration. Genetic deletion of FAP further slowed IDD progression. Collectively, these findings provide compelling evidence that FAP\u2010\u03b1 accelerates IDD by promoting angiogenesis, which disrupts disc homeostasis. Targeting FAP\u2010\u03b1 may offer a novel therapeutic approach for mitigating IDD.<\/jats:p>","DOI":"10.1111\/cpr.70162","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:41:04Z","timestamp":1768376464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibition of Fibroblast Activation Protein\u2010\u03b1 Ameliorates Intervertebral Disc Degeneration via Reduced Vascular Invasion in Cartilage Endplate"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8653-9521","authenticated-orcid":false,"given":"Hao\u2010Wei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Spinal Surgery Shanghai East Hospital, School of Medicine, Tongji University  Shanghai 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