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Agrimoniin has been shown to possess antioxidant and anti\u2010inflammatory properties, making it a potential therapeutic agent for organ preservation. This study investigated whether supplementing agrimoniin to the University of Wisconsin (UW) cold storage solution protected liver grafts from DCD rats or cold preserved human liver cell lines (QSG\u20107701 and HepG2). Agrimoniin supplementation significantly reduced oxidative damage, alleviated ferroptosis, and mitigated liver injury by activating the Nrf\u20102 pathway, both in\u00a0vivo and in\u00a0vitro. These findings suggest that ferroptosis is a mediator in DCD liver injury, and agrimoniin, through its activation of the Nrf\u20102 pathway, may be an effective therapeutic agent for enhancing liver graft preservation and improving outcomes in DCD liver transplantation.<\/jats:p>","DOI":"10.1111\/cpr.70164","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T22:40:21Z","timestamp":1768948821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Agrimoniin Alleviates Ferroptosis in Cold\u2010Stored\n                    <scp>DCD<\/scp>\n                    Liver Grafts Through Activation of the Nrf\u20102 Pathway"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7415-8845","authenticated-orcid":false,"given":"Enqiang","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Guangxi Medical University Cancer Hospital, 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