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This condition represents a major public health concern since it causes multisystem complications, including microvascular diseases, macrovascular diseases, and neuropathy. Few effective therapies are currently available. Ferroptosis, an iron\u2010dependent mode of regulated cell death triggered by lipid peroxidation (LPO), is intricately linked to the pathogenesis, progression, and complications of DM. It has been increasingly recognised as a key mechanism underlying peripheral insulin resistance and insulin deficiency resulting from \u03b2\u2010cell dysfunction. In this study, we systematically summarised the primary regulatory mechanisms of ferroptosis and outlined current research advancements in mechanistic insights into its role in diabetic complications. Besides, we explored how inter\u2010organelle interactions drive ferroptosis under diabetic conditions and play pathogenic effects in diabetes and its complications. Finally, we systematically reviewed the therapeutic drugs targeting ferroptosis from the perspectives of traditional Chinese medicine (TCM) and Western medicine, respectively. This interdisciplinary integrated overview may provide a theoretical basis for future clinical transformation.<\/jats:p>","DOI":"10.1111\/cpr.70187","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:18:05Z","timestamp":1772957885000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2595-6164","authenticated-orcid":false,"given":"Zheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"},{"name":"Academy of Medical Sciences Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"},{"name":"Henan Province Research Center for Kidney Disease The First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"},{"name":"Academy of Medical Sciences Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"},{"name":"Academy of Medical Sciences Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyue","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Henan University of Science and Technology  Luoyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaona","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"},{"name":"Academy of Medical Sciences Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-5710","authenticated-orcid":false,"given":"Qi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"},{"name":"Henan Province Research Center for Kidney Disease The First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"IDF Diabetes Atlas","author":"Magliano D. 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