{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:19:13Z","timestamp":1783448353295,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013129","name":"Ministry of SMEs and Startups","doi-asserted-by":"publisher","award":["RS\u20102024\u201000488530"],"award-info":[{"award-number":["RS\u20102024\u201000488530"]}],"id":[{"id":"10.13039\/501100013129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Huntington's disease (HD) is an inherited neurodegenerative disease characterised by progressive degeneration of GABAergic medium spiny neurons (MSNs) in the striatum. Neural precursor cells (NPCs) derived from human induced pluripotent stem cells (iPSCs) have been considered as a promising and scalable source for neuronal replacement and circuit restoration. In this study, we investigated the therapeutic effects of a clinical\u2010grade, human leukocyte antigen (HLA)\u2010homozygous iPSC line (YZWJ\u2010s513) differentiated into NPCs (s513\u2010NPCs) in a quinolinic acid (QA)\u2010lesioned rat model of HD. Following intrastriatal transplantation, s513\u2010NPCs not only survived for 12\u2009weeks but also differentiated into neurons, astrocytes, and oligodendrocytes, while generating new DARPP32\n                    <jats:sup>+<\/jats:sup>\n                    GABAergic MSNs. Specifically, graft\u2010derived neurons projected to the host globus pallidus, indicating structural integration into the striato\u2010pallidal pathways. Additionally, NPC\u2010transplanted rats exhibited significant motor recovery across multiple tasks for up to 12\u2009weeks, accompanied by reduced striatal atrophy and ventricular enlargement. Histological findings also revealed attenuated astrogliosis and microgliosis, along with a shift toward an anti\u2010inflammatory milieu. Collectively, these results demonstrate that transplantation of clinical\u2010grade, HLA\u2010homozygous iPSC\u2010derived NPCs can provide both neuronal replacement and modulation of the diseased microenvironment, supporting their potential as a regenerative therapy for HD. Key quality attributes and release criteria supporting the clinical\u2010grade characterisation of the cell product used in\u00a0vivo are summarised in Table\u00a0.\n                  <\/jats:p>","DOI":"10.1111\/cpr.70189","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:18:07Z","timestamp":1772957887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical\u2010Grade Human Induced Pluripotent Stem Cell\u2010Derived Neural Precursor Cells Restore Motor Function and Preserve Striatal Integrity in a Quinolinic Acid\u2010Lesioned Rat Model of Huntington's Disease"],"prefix":"10.1111","volume":"59","author":[{"given":"Hyeonjoong","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences CHA University  Seongnam\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il\u2010Shin","family":"Lee","sequence":"additional","affiliation":[{"name":"iPS Bio, Inc.  Seongnam\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences CHA University  Seongnam\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Chang","family":"Park","sequence":"additional","affiliation":[{"name":"iPS Bio, Inc.  Seongnam\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beomsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"iPS Bio, Inc.  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