{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:12:33Z","timestamp":1788581553244,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1100600"],"award-info":[{"award-number":["2021YFA1100600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370927"],"award-info":[{"award-number":["82370927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone loss. Osteoclasts (OCs) are the key cells mediating bone resorption and their excessive formation disrupts bone homeostasis. Since apoptosis of OCs normally restrains this process, its failure can sustain bone loss. However, its role in periodontitis remains unclear. Analysis of single\u2010cell RNA sequencing (scRNA\u2010seq) data retrieved from the Gene Expression Omnibus (GEO) database revealed impaired OC apoptosis in the periodontal tissues of individuals suffering from periodontitis. Notably, we observed a reduction in cytoskeleton\u2010associated protein 4 (CKAP4) expression correlating with decreased OC apoptosis. Further investigations using\n                    <jats:italic>Ckap4<\/jats:italic>\n                    knockout mice confirmed that CKAP4 promotes OC apoptosis through the activation of forkhead box O3 (FOXO3)\u2010induced endoplasmic reticulum stress (ERS). CKAP4 regulates OC apoptosis to maintain periodontal homeostasis and its downregulation in periodontitis promotes pathological bone resorption. This study elucidates CKAP4\u2010mediated apoptotic pathways in OCs, providing mechanistic insight and potential therapeutic strategies to restore OC balance and prevent bone loss.\n                  <\/jats:p>","DOI":"10.1111\/cpr.70208","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:40:55Z","timestamp":1776069655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CKAP4<\/scp>\n                    Regulates\n                    <scp>ERS<\/scp>\n                    \u2010Induced Apoptosis in Osteoclasts Through\n                    <scp>FOXO3<\/scp>\n                    in Periodontitis"],"prefix":"10.1111","volume":"59","author":[{"given":"Jiayu","family":"Cheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases. Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dihao","family":"Tao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases. Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhe","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases. Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases. Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhe","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases. Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases. Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases. Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases. Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases. Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases. Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases. 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