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Embedded in a nutrient\u2010limited matrix and burdened by cumulative stress over their exceptionally long lifespan, how osteocytes sustain long\u2010term viability remains elusive. Tunnelling nanotubes (TNTs) are newly described intercellular bridges that enable long\u2010range transfer of organelles and have been implicated in stress adaptation. Here, we provide the first definitive identification of TNTs between cultured osteocytes, which exhibit canonical TNT morphology together with osteocyte\u2010specific features. Functionally, osteocytic TNTs mediate intercellular transfer of membrane\u2010bound cargo, predominantly lysosomes. Under nutrient deprivation, TNT formation and lysosome transfer are both increased, replenishing the lysosomal pool in stressed osteocytes. Transferred lysosomes then fuse with accumulated autophagosomes, thereby restoring impaired autophagic flux and suppressing apoptosis. This cytoprotective effect requires TNT integrity and intact autophagic flux. Although mitochondrial transfer is detectable, it does not confer comparable protection. The findings identify a transcellular autophagy pathway mediated by TNT\u2010dependent lysosome sharing, revealing a previously unrecognized cooperative survival strategy among osteocytes. This work establishes a novel conceptual framework in osteocyte biology and suggests potential therapeutic avenues for bone diseases associated with osteocyte apoptosis and impaired bone remodelling.<\/jats:p>","DOI":"10.1111\/cpr.70226","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:47:56Z","timestamp":1778820476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tunnelling Nanotube\u2010Mediated Lysosome Sharing Promotes Osteocyte Survival via Transcellular Autophagy"],"prefix":"10.1111","volume":"59","author":[{"given":"Jinbiao","family":"Qiang","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Hospital of Stomatology Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Oral and Craniofacial Diseases &amp; Tissue Reconstruction  Changchun China"},{"name":"Key Laboratory of Pathobiology, Ministry of Education Jilin 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