{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:45:37Z","timestamp":1791773137513,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271092"],"award-info":[{"award-number":["82271092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571230"],"award-info":[{"award-number":["82571230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Retinal neovascular diseases, such as retinopathy of prematurity and diabetic retinopathy, threaten vision by disrupting retinal structure and function through pathological neovascularisation and chronic inflammation. Existing anti\u2010VEGF therapies primarily target angiogenesis, offering limited control over inflammation and requiring repeated administration. Here, we developed a resveratrol (RSV)\u2010loaded tetrahedral framework nucleic acid nanostructure (tFNAs\u2010RSV) to achieve concurrent anti\u2010angiogenic and anti\u2010inflammatory effects. tFNAs provided a biocompatible, stable and penetration\u2010efficient carrier that enhanced RSV ocular delivery and bioactivity. In hypoxia\u2010induced retinal neovascularisation models, tFNAs\u2010RSV markedly reduced neovascular lesion area, vascular leakage and retinal inflammatory cell infiltration. Mechanistically, tFNAs\u2010RSV suppressed HIF\u20101 signalling and inhibited the p38 MAPK pathway and NF\u2010\u03baB p65 pathway. Collectively, these results validate tFNAs\u2010RSV as a promising nanoplatform for treating retinal neovascular diseases, with an emphasis on inhibiting neovascularisation and inflammation.<\/jats:p>","DOI":"10.1111\/cpr.70227","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:27:37Z","timestamp":1780489657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Suppression of Retinal Neovascularisation by Tetrahedral Framework Nucleic Acids\u2010Resveratrol Via Dual Anti\u2010Angiogenesis and Anti\u2010Inflammation"],"prefix":"10.1111","volume":"59","author":[{"given":"Yili","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Cai","sequence":"additional","affiliation":[{"name":"Sichuan Eye Medical Center, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyang","family":"Huang","sequence":"additional","affiliation":[{"name":"Sichuan Eye Medical Center, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Sichuan Eye Medical Center, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine Southern Medical University  Guangzhou China"},{"name":"Department of Ophthalmology, General Hospital of Central Theater Command  Wuhan 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