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Here, we define Zeb2 as a pivotal transcriptional modulator of retinal astrocyte function that coordinates developmental and pathological vascular growth. It is transiently expressed in retinal astrocyte progenitor cells during development and re\u2010induced under pathological hypoxia. Conditional ablation of\n                    <jats:italic>Zeb2<\/jats:italic>\n                    in retinal astrocytes enhanced their proliferation, migration, and maturation by upregulating VEGFA and altering other signalling, leading to excessive superficial vascular growth during development. In oxygen\u2010induced retinopathy,\n                    <jats:italic>Zeb2<\/jats:italic>\n                    inactivation exacerbated pathological neovascularization while impairing reparative revascularization, which is associated with a transcriptional signature favouring tuft ECs over tip ECs. Mechanistically, it inhibited the neurotoxic A1 astrocyte identity, resulting in dampened inflammatory response and diminished genetic program promoting revascularization and\/or preventing neovascularization including Plxnd1, Nrf2, and FGF2 signalling. These findings establish Zeb2 as an oxygen\u2010sensitive regulator of astrocyte function that differentially modulates physiological and pathological angiogenesis, highlighting its potential as a therapeutic target in proliferative retinopathies.\n                  <\/jats:p>","DOI":"10.1111\/cpr.70236","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T09:54:32Z","timestamp":1779789272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation"],"prefix":"10.1111","volume":"59","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat\u2010sen University  Guangzhou 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