{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:45:24Z","timestamp":1782960324177,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Colorectal cancer (CRC) is the third most common malignancy worldwide. Epidemiological studies have suggested a positive association between periodontitis (PD) and CRC risk; however, the mechanistic basis underlying this relationship remains unclear. Extracellular vesicles (EVs) represent an important mode of systemic communication and may mediate the distal effects between PD and CRC. PD model was established in\n                    <jats:italic>Apc<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice with spontaneous intestinal tumorigenesis. Tumour onset, burden, and progression were evaluated in the colorectum and small intestine. Circulating EVs were isolated from the plasma of PD or sham mice and characterised. The functional contribution of EVs was assessed using pharmacological inhibition of EV release and MC38 syngeneic tumour models. Metabolomic profiling, RNA sequencing, and in\u00a0vitro functional assays were performed to investigate EV cargo and underlying mechanisms. PD significantly accelerated CRC onset and increased tumour number and size in\n                    <jats:italic>Apc<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice. Inhibition of EV release by GW4869 attenuated PD\u2010driven tumour progression, indicating a critical role of periodontitis\u2010associated EVs (PDEVs). PDEVs promoted tumour growth and induced an immunosuppressive tumour microenvironment in MC38 transplanted tumours. Metabolomic analysis revealed marked enrichment of carnosine in PDEVs. Under acidic conditions, EV\u2010delivered carnosine alleviated intracellular acidosis, preserved lysosomal positioning and acidification, and promoted proliferation, migration, and epithelial\u2013mesenchymal transition of MC38 cells. Collectively, circulating EV\u2010mediated metabolic communication pathway linking PD to CRC progression. By delivering carnosine, PDEVs support malignant phenotypes and facilitate tumour adaptation to acidic stress. Circulating EV\u2010associated carnosine may represent a potential biomarker and a candidate target for modulating CRC progression in high\u2010risk populations.\n                  <\/jats:p>","DOI":"10.1111\/cpr.70254","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:10:45Z","timestamp":1782958245000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontitis\u2010Associated Circulating\n                    <scp>EVs<\/scp>\n                    Promote Colorectal Cancer Progression via Carnosine\u2010Mediated Acidosis Adaptation"],"prefix":"10.1111","author":[{"given":"Ruoyi","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualing","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haikun","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bicheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-7250","authenticated-orcid":false,"given":"Yueqi","family":"Ni","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8702-5291","authenticated-orcid":false,"given":"Yufeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"},{"name":"Medical Research Institute, School of Medicine Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/prd.12145","article-title":"Periodontitis Prevalence in Adults \u2265\u200965\u2009Years of Age, in the USA","volume":"72","author":"Eke P. I.","year":"2016","journal-title":"Periodontology 2000"},{"issue":"2","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/jcpe.13396","article-title":"The Prevalence and Severity of Periodontal Disease in Mainland China: Data From the Fourth National Oral Health Survey (2015\u20102016)","volume":"48","author":"Jiao J.","year":"2021","journal-title":"Journal of Clinical Periodontology"},{"issue":"3","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/00220345231221709","article-title":"Impact of Periodontitis on the Leakage of Oral Bacteria to the Gut","volume":"103","author":"Buetas E.","year":"2024","journal-title":"Journal of Dental Research"},{"issue":"12","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1002\/JPER.22-0035","article-title":"Circulating Small Extracellular Vesicles From Patients With Periodontitis Contribute to Development of Insulin Resistance","volume":"93","author":"Wang F.","year":"2022","journal-title":"Journal of Periodontology"},{"issue":"11","key":"e_1_2_10_6_1","article-title":"Immunoinflammatory Mechanisms Connecting Periodontitis and Solid Tumors: A Systematic Review of Original Evidence","volume":"17","author":"El Ayachi H.","year":"2025","journal-title":"Cureus"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"Periodontitis and Atherosclerotic Cardiovascular Disease: A Critical Appraisal","author":"Carra M. C.","year":"2023","journal-title":"Periodontology 2000"},{"issue":"1","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00125-011-2342-y","article-title":"Periodontitis and Diabetes: A Two\u2010Way Relationship","volume":"55","author":"Preshaw P. M.","year":"2012","journal-title":"Diabetologia"},{"issue":"10","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1007\/s12094-023-03162-0","article-title":"Periodontitis and Progression of Gastrointestinal Cancer: Current Knowledge and Future Perspective","volume":"25","author":"Nasiri K.","year":"2023","journal-title":"Clinical & Translational Oncology"},{"issue":"1","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1186\/s12889-025-21832-2","article-title":"Periodontitis and Gastrointestinal Cancer: A Nationwide Cohort Study of NHANES 2009\u20102014","volume":"25","author":"Pu K.","year":"2025","journal-title":"BMC Public Health"},{"issue":"6","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1177\/00220345231158269","article-title":"Ligature\u2010Induced Periodontitis Drives Colorectal Cancer: An Experimental Model in Mice","volume":"102","author":"Shi Y. T.","year":"2023","journal-title":"Journal of Dental Research"},{"issue":"10","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1177\/00220345241263768","article-title":"Association Between Periodontal Diseases and the Risk of Site\u2010Specific Gastrointestinal Cancers: A Systematic Review and Meta\u2010Analysis","volume":"103","author":"Wang Q.","year":"2024","journal-title":"Journal of Dental Research"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/jcpe.70063","article-title":"Dysbiosis\u2010Mediated Inflammation: A Pathophysiological Link Between Rheumatoid Arthritis and Periodontitis","volume":"53","author":"Lopez\u2010Oliva I.","year":"2025","journal-title":"Journal of Clinical Periodontology"},{"issue":"3","key":"e_1_2_10_14_1","first-page":"173","article-title":"Evidence Accumulates Indicating Periodontal Disease as a Risk Factor for Colorectal Cancer or Lymphoma","volume":"67","author":"Barton M. K.","year":"2017","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"5","key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/jcpe.13769","article-title":"Prevalence of Periodontitis in Dentate People Between 2011 and 2020: A Systematic Review and Meta\u2010Analysis of Epidemiological Studies","volume":"50","author":"Trindade D.","year":"2023","journal-title":"Journal of Clinical Periodontology"},{"issue":"3","key":"e_1_2_10_16_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung H.","year":"2021","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"1","key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/00220345241281698","article-title":"Global, Regional, and Country\u2010Level Economic Impacts of Oral Conditions in 2019","volume":"104","author":"Jevdjevic M.","year":"2025","journal-title":"Journal of Dental Research"},{"issue":"6","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1111\/odi.15260","article-title":"Association Between Intestinal Diseases and Periodontitis: A Systematic Review and Meta\u2010Analysis","volume":"31","author":"Wu Y.","year":"2025","journal-title":"Oral Diseases"},{"issue":"17","key":"e_1_2_10_19_1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm14176334","article-title":"Association Between Periodontitis and Cancer: A Perspective Review of Mechanisms and Clinical Evidence","volume":"14","author":"Bonilla M.","year":"2025","journal-title":"Journal of Clinical Medicine"},{"issue":"49","key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"5253","DOI":"10.1038\/s41388-022-02520-6","article-title":"Extracellular Vesicles\u2010Transferred SBSN Drives Glioma Aggressiveness by Activating NF\u2010\u03baB via ANXA1\u2010Dependent Ubiquitination of NEMO","volume":"41","author":"Chen H.","year":"2022","journal-title":"Oncogene"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102174","article-title":"Ferroptosis\u2010Dependent Extracellular Vesicles From Macrophage Contribute to Asbestos\u2010Induced Mesothelial Carcinogenesis Through Loading Ferritin","volume":"47","author":"Ito F.","year":"2021","journal-title":"Redox Biology"},{"issue":"1","key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12951-022-01382-0","article-title":"Extracellular Vesicle\u2010Mediated Crosstalk Between Pancreatic Cancer and Stromal Cells in the Tumor Microenvironment","volume":"20","author":"Li Y.","year":"2022","journal-title":"Journal of Nanobiotechnology"},{"issue":"5","key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41590-021-00899-0","article-title":"Extracellular Vesicles in Immunomodulation and Tumor Progression","volume":"22","author":"Marar C.","year":"2021","journal-title":"Nature Immunology"},{"issue":"3","key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41590-023-01719-3","article-title":"Carnosine Regulation of Intracellular pH Homeostasis Promotes Lysosome\u2010Dependent Tumor Immunoevasion","volume":"25","author":"Yan R. H.","year":"2024","journal-title":"Nature Immunology"},{"issue":"1","key":"e_1_2_10_25_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.xcrm.2025.102534","article-title":"Cathepsin\u2010D\u2010Mediated MHC Class I Degradation Contributes to Immune Evasion in Colorectal Cancer","volume":"7","author":"Zhan W.","year":"2026","journal-title":"Cell Reports Medicine"},{"issue":"4","key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/CIRCRESAHA.122.321939","article-title":"Circulating Extracellular Vesicle\u2010Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease","volume":"132","author":"Koide T.","year":"2023","journal-title":"Circulation Research"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113961","article-title":"Dosing Extracellular Vesicles","volume":"178","author":"Gupta D.","year":"2021","journal-title":"Advanced Drug Delivery Reviews"},{"issue":"2","key":"e_1_2_10_28_1","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12310","article-title":"Hypoxia Promotes EV Secretion by Impairing Lysosomal Homeostasis in HNSCC Through Negative Regulation of ATP6V1A by HIF\u20101 Alpha","volume":"12","author":"Wang X. N.","year":"2023","journal-title":"Journal of Extracellular Vesicles"},{"issue":"1","key":"e_1_2_10_29_1","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1703244","article-title":"Inhibiting Extracellular Vesicles Formation and Release: A Review of EV Inhibitors","volume":"9","author":"Catalano M.","year":"2020","journal-title":"Journal of Extracellular Vesicles"},{"issue":"1","key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/glia.24624","article-title":"Endogenous Histidine Peptides Are Physiological Antioxidants That Prevent Oligodendrocyte Cell Death and Myelin Loss In\u00a0Vivo","volume":"73","author":"Sajrawi C.","year":"2025","journal-title":"Glia"},{"issue":"1","key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"W98","DOI":"10.1093\/nar\/gkx247","article-title":"GEPIA: A Web Server for Cancer and Normal Gene Expression Profiling and Interactive Analyses","volume":"45","author":"Tang Z.","year":"2017","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41420-025-02561-2","article-title":"DNMBP\u2010AS1\/Hsa\u2010miR\u201030a\u20105p\/PGC1\u03b1 Axis Suppresses Tumor Progression of Colorectal Cancer by Inhibiting PKM2\u2010Mediated Warburg Effect and Enhance Anti\u2010PD\u20101 Therapy Efficacy","volume":"11","author":"Wang T.","year":"2025","journal-title":"Cell Death Discovery"},{"issue":"1","key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41419-025-07457-8","article-title":"Transcription Factor ONECUT3 Regulates HDAC6\/HIF\u20101\u03b1 Activity to Promote the Warburg Effect and Tumor Growth in Colorectal Cancer","volume":"16","author":"Huo R.","year":"2025","journal-title":"Cell Death & Disease"},{"key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-physiol-021119-034627","article-title":"The Acidic Tumor Microenvironment as a Driver of Cancer","volume":"82","author":"Boedtkjer E.","year":"2020","journal-title":"Annual Review of Physiology"},{"issue":"6","key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41551-024-01178-7","article-title":"Severely Polarized Extracellular Acidity Around Tumour Cells","volume":"8","author":"Feng Q.","year":"2024","journal-title":"Nature Biomedical Engineering"},{"issue":"6478","key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.aau6977","article-title":"The Biology, Function, and Biomedical Applications of Exosomes","volume":"367","author":"Kalluri R.","year":"2020","journal-title":"Science"},{"issue":"7565","key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nature14587","article-title":"Transcriptional Control of Autophagy\u2010Lysosome Function Drives Pancreatic Cancer Metabolism","volume":"524","author":"Perera R.","year":"2015","journal-title":"Nature"},{"issue":"29","key":"e_1_2_10_38_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb3713","article-title":"GADL1 Is a Multifunctional Decarboxylase With Tissue\u2010Specific Roles in \u03b2\u2010Alanine and Carnosine Production","volume":"6","author":"Mahootchi E.","year":"2020","journal-title":"Science Advances"}],"container-title":["Cell Proliferation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpr.70254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cpr.70254","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpr.70254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:10:50Z","timestamp":1782958250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpr.70254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":37,"alternative-id":["10.1111\/cpr.70254"],"URL":"https:\/\/doi.org\/10.1111\/cpr.70254","archive":["Portico"],"relation":{},"ISSN":["0960-7722","1365-2184"],"issn-type":[{"value":"0960-7722","type":"print"},{"value":"1365-2184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"2026-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70254"}}