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Mounting evidence shows that K\n                    <jats:sub>L\u2010la<\/jats:sub>\n                    has pivotal roles in transcription regulation and diverse cellular processes and is implicated in multiple pathophysiological conditions. This review comprehensively examines K\n                    <jats:sub>L\u2010la<\/jats:sub>\n                    across both histone and non\u2010histone substrates in biology and disease. We first illustrate the historical development of K\n                    <jats:sub>L\u2010la<\/jats:sub>\n                    and distinguish it from its isomers. We then delineate the enzymes regulating K\n                    <jats:sub>L\u2010la<\/jats:sub>\n                    , examine its crosstalk with other PTMs, and discuss its roles in cell signalling and other biological processes. Particular emphasis is placed on mechanisms through which K\n                    <jats:sub>L\u2010la<\/jats:sub>\n                    contributes to various human diseases such as cancer, viral infections, neurodegenerative disorders, cardiovascular conditions, metabolic abnormalities and immune dysregulation. Finally, we provide an in\u2010depth analysis of emerging therapeutic strategies targeting K\n                    <jats:sub>L\u2010la<\/jats:sub>\n                    and highlight future directions for translating mechanistic insights into clinical applications.\n                  <\/jats:p>","DOI":"10.1111\/cpr.70262","type":"journal-article","created":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T23:01:46Z","timestamp":1783897306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lysine\n                    <scp>l<\/scp>\n                    \u2010Lactylation: Bridging Metabolism, Chromatin and Disease"],"prefix":"10.1111","volume":"59","author":[{"given":"Anoosha","family":"Malik","sequence":"first","affiliation":[{"name":"Department of Biopharmaceutics, Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Science and Medicine Zhejiang Sci\u2010Tech University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Dilawar","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics, Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Science and Medicine Zhejiang Sci\u2010Tech University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junguang","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics, Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Science and Medicine Zhejiang Sci\u2010Tech University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The 903rd Hospital of the Joint Logistic Support Force  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qitao","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics, Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Science and Medicine Zhejiang Sci\u2010Tech University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics, Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Science and Medicine Zhejiang Sci\u2010Tech University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics, Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Science and Medicine Zhejiang Sci\u2010Tech University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery The First Affiliated Hospital, School of Medicine, Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuwei","family":"Ge","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Zhejiang Rehabilitation Medical Center  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Jin","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, The Second Hospital of Jiaxing, The Second Affiliated Hospital of Jiaxing University  Jiaxing 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