{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:06:03Z","timestamp":1784365563316,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20397"],"award-info":[{"award-number":["U20A20397"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A6012"],"award-info":[{"award-number":["U23A6012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2020B1111100005"],"award-info":[{"award-number":["2020B1111100005"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2020B1111100006"],"award-info":[{"award-number":["2020B1111100006"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Autoimmune diseases, including psoriasis (Ps), rheumatoid arthritis (RA) and ulcerative colitis (UC), pose significant health burdens worldwide. A more refined classification of these diseases is essential for enabling targeted therapeutic strategies. Traditional Chinese Medicine (TCM) is gaining increasing recognition globally, offering potential insights into disease heterogeneity. In this study, we performed comprehensive T cell receptor (TCR) and B cell receptor (BCR) repertoire sequencing in 59 participants, including patients with Ps, RA, UC and healthy controls. Patients were further stratified into Dampness and non\u2010Dampness groups based on standardized TCM diagnostic criteria. Repertoire composition, clonotype richness, diversity metrics, V gene usage and shared CDR3 patterns were analysed. Machine learning approaches (LASSO, GLM and OPLS\u2010DA) were applied to identify diagnostic biomarkers, followed by validation in an independent cohort. Compared with healthy controls, Ps, RA and UC patients exhibited reduced clonotype richness and diminished TCR\/BCR diversity, indicating adaptive immune contraction. Dampness ZHENG\u2010specific alterations were observed, including selective IgK and IgL clonotype richness reduction in Ps with dampness, increased TRA\/TRB diversity in RA with dampness, and elevated TRG clonotype counts\/read proportions in UC with dampness. Stratification by Dampness ZHENG revealed distinct immune repertoire architectures characterized by increased D50 index, reduced proportions of large clones and preferential V gene usage, including\n                    <jats:italic>TRAV20<\/jats:italic>\n                    ,\n                    <jats:italic>TRAV38\u20102DV8<\/jats:italic>\n                    and\n                    <jats:italic>TRAV8\u20103<\/jats:italic>\n                    . Unsupervised dimensionality reduction demonstrated significant separation between Dampness and non\u2010Dampness groups across diseases. A three\u2010gene V\u2010segment model achieved an AUC of 0.804 and 74.7% accuracy in an independent validation cohort, supporting its potential utility as an objective biomarker for Dampness ZHENG. Our findings suggest that TCM\u2010based phenotyping may offer a meaningful approach for subgrouping autoimmune diseases, thereby providing a foundation for more syndrome differentiation\u2010based treatment strategies.\n                  <\/jats:p>","DOI":"10.1111\/cpr.70265","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T08:34:26Z","timestamp":1784363666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune Repertoire Profiling Reveals Distinct Adaptive Immune Signatures of Dampness\n                    <scp>ZHENG<\/scp>\n                    Across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8760-9331","authenticated-orcid":false,"given":"Lipeng","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong\u2010Hong Kong\u2010Macau Joint Lab on Chinese Medicine and Immune Disease Research The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Department of Pharmacology of Traditional Chinese Medicine The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-416X","authenticated-orcid":false,"given":"Maojie","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong\u2010Hong Kong\u2010Macau Joint Lab on Chinese Medicine and Immune Disease Research The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou 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Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youbang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Clinical and Basic Research The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Clinical and Basic Research The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Clinical and Basic Research The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5770-4269","authenticated-orcid":false,"given":"Kaixin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Clinical and Basic Research The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou 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Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care Hospital  Changsha Hunan China"},{"name":"Institute for Future Sciences, University of South China  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8852-4364","authenticated-orcid":false,"given":"Xinjie","family":"Yu","sequence":"additional","affiliation":[{"name":"Hengyang Medical School University of South China  Hengyang Hunan China"},{"name":"National Health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care Hospital  Changsha Hunan China"},{"name":"Institute for Future Sciences, University of South China  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Pan","sequence":"additional","affiliation":[{"name":"Hengyang Medical School University of South China  Hengyang Hunan 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Immune Disease Research The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Department of Rheumatology Clinical and Basic Research The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5570-2470","authenticated-orcid":false,"given":"Guangjuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Department of Pathology The Second Clinical College of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanjian","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Clinical College of 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