{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:51:26Z","timestamp":1791348686792,"version":"4.3.1"},"reference-count":70,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC3408800"],"award-info":[{"award-number":["2025YFC3408800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFB4607800"],"award-info":[{"award-number":["2024YFB4607800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Bioadhesives have traditionally been viewed as materials for wound closure, sealing and haemostasis However, in tissue repair they also create the first engineered interface that influences cell retention, microenvironmental homeostasis and subsequent remodelling Recent advances in 3D printing are shifting bioadhesives from passive, uniform layers to architecturally controlled interfaces with spatially programmable chemistry, mechanics, transport and biological function. In this Review, we propose an interface\u2010centred framework in which qualifying 3D\u2010printed bioadhesive interfaces function as proliferative niches. Such interfaces require stable host\u2010tissue adhesion and a biocompatible, cell\u2010permissive microenvironment. They should also measurably support cell survival, context\u2010appropriate proliferation and constructive remodelling in defined target\u2010cell populations. We summarize the key design principles that govern proliferative\u2010niche formation, with printability\u2010aware fabrication treated as a cross\u2010cutting prerequisite for implementing interfacial adhesion, mechanical matching, mass transport, surface chemistry and temporal evolution. We then discuss the mechanistic basis through which printed bioadhesive interfaces regulate early protein adsorption, immune activation, mechanotransduction, metabolic exchange and long\u2010term remodelling trajectories. Representative application contexts, including sealing and haemostasis musculoskeletal repair, wearable and implantable biointerfaces and organoid\u2010related in\u00a0vitro models, are examined to highlight application\u2010specific opportunities and trade\u2010offs. We further outline emerging evaluation and modelling frameworks that move beyond adhesion strength towards multidimensional assessment, cross\u2010scale structure\u2013property\u2013function mapping and data\u2010driven predictive design. By reframing bioadhesives as active interfacial regulators rather than passive fixation materials, this Review provides a conceptual framework for engineering 3D\u2010printed bioadhesives that not only adhere and seal, but also actively guide constructive tissue repair.<\/jats:p>","DOI":"10.1111\/cpr.70286","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:29:32Z","timestamp":1791347372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>3D<\/scp>\n                    \u2010Printed Bioadhesive Interfaces as Proliferative Niches for Tissue Repair"],"prefix":"10.1111","author":[{"given":"Zhen","family":"Gu","sequence":"first","affiliation":[{"name":"School of Chemistry and Biological Engineering, University of Science and Technology Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyong","family":"Su","sequence":"additional","affiliation":[{"name":"School of Chemistry and Biological Engineering, University of Science and Technology Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6496-3155","authenticated-orcid":false,"given":"Guoshi","family":"Xu","sequence":"additional","affiliation":[{"name":"Human Organ Physiopathology Emulation System, State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences  Beijing China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-4166","authenticated-orcid":false,"given":"Yongqiang","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Chemistry and Biological Engineering, University of Science and Technology Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9387-9525","authenticated-orcid":false,"given":"Qi","family":"Gu","sequence":"additional","affiliation":[{"name":"Human Organ Physiopathology Emulation System, State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences  Beijing China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/adtp.202300139","article-title":"Designing Regenerative Bioadhesives for Tissue Repair and Regeneration","volume":"7","author":"Li X.","year":"2023","journal-title":"Advances in Therapy"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.progpolymsci.2024.101792","article-title":"Multifunctional Naturally Derived Bioadhesives: From Strategic Molecular Design Toward Advanced Biomedical Applications","volume":"150","author":"Kharaziha M.","year":"2024","journal-title":"Progress in Polymer Science"},{"issue":"3","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202300379","article-title":"Stimuli\u2010Responsive Hydrogel Adhesives for Wound Closure and Tissue Regeneration","volume":"24","author":"Ren H.","year":"2024","journal-title":"Macromolecular Bioscience"},{"issue":"18","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"8835","DOI":"10.1021\/acs.chemrev.5c00182","article-title":"Therapeutic Hydrogels: Properties and Biomedical Applications","volume":"125","author":"Dong S.","year":"2025","journal-title":"Chemical Reviews"},{"issue":"2","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202403734","article-title":"Multifunctional Adhesive Hydrogels: From Design to Biomedical Applications","volume":"14","author":"Tang S.","year":"2025","journal-title":"Advanced Healthcare Materials"},{"issue":"1","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/s41467-024-45147-9","article-title":"A 3D Printable Tissue Adhesive","volume":"15","author":"Wu S. 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