{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:34:56Z","timestamp":1761975296639},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T00:00:00Z","timestamp":1351036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Gastro\u2010oesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GORD<\/jats:styled-content>) is suggested to cause or aggravate several respiratory conditions. Studies with proton pump inhibitors have resulted in only minor improvements in pulmonary outcomes in patients with <jats:styled-content style=\"fixed-case\">GORD<\/jats:styled-content>. It has been speculated that operative treatment of <jats:styled-content style=\"fixed-case\">GORD<\/jats:styled-content> might be more efficient as it also diminishes non\u2010acidic reflux.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the effects of esomeprazole 40\u2009mg bid and fundoplication on airway responsiveness, forced expiratory volume in 1\u2009s (<jats:styled-content style=\"fixed-case\">FEV<jats:sub>1<\/jats:sub><\/jats:styled-content>), exhaled nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>) and respiratory symptoms in patients with moderate\u2010to\u2010severe <jats:styled-content style=\"fixed-case\">GORD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010nine <jats:styled-content style=\"fixed-case\">GORD<\/jats:styled-content> patients had methacholine inhalation challenge performed on them, and <jats:styled-content style=\"fixed-case\">FEV<jats:sub>1<\/jats:sub><\/jats:styled-content>, exhaled <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> and respiratory symptoms were measured at baseline, after a 3\u2010month treatment with esomeprazole and 3 months after fundoplication. Primary outcome variable was dose\u2010response slope (<jats:styled-content style=\"fixed-case\">DRS<\/jats:styled-content>), i.e. decline in <jats:styled-content style=\"fixed-case\">FEV<jats:sub>1<\/jats:sub><\/jats:styled-content> during methacholine challenge divided with the amount of methacholine administered (%\/\u03bcmol). Pre\u2010defined subgroup analysis was performed among those with concomitant asthma (<jats:italic>n<\/jats:italic>\u2009=\u200912).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no improvement in <jats:styled-content style=\"fixed-case\">DRS<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">FEV<jats:sub>1<\/jats:sub><\/jats:styled-content> or exhaled <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> after esomeprazole treatment or fundoplication. Cough and dyspnoea measured with visual analog scale improved with esomeprazole treatment (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and further after fundoplication (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Among those with concomitant asthma, significant improvements in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>t <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>eorge <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>espiratory <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire (<jats:styled-content style=\"fixed-case\">SGRQ<\/jats:styled-content>) scores could be seen after fundoplication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neither esomeprazole treatment nor fundoplication diminishes airway responsiveness or exhaled <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>, or improves <jats:styled-content style=\"fixed-case\">FEV<jats:sub>1<\/jats:sub><\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">GORD<\/jats:styled-content>. Improvements in respiratory symptoms and <jats:styled-content style=\"fixed-case\">SGRQ<\/jats:styled-content> scores after <jats:styled-content style=\"fixed-case\">GORD<\/jats:styled-content> treatments could be detected. However, as this was not a placebo\u2010controlled study, the findings in these secondary endpoints should not be emphasised. <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linical<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rials.cov: <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>00994708.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12005","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T11:55:24Z","timestamp":1348487724000},"page":"281-287","source":"Crossref","is-referenced-by-count":22,"title":["Comparison of the effects of esomeprazole and fundoplication on airway responsiveness in patients with gastro\u2010oesophageal reflux disease"],"prefix":"10.1111","volume":"7","author":[{"given":"Toni","family":"Kiljander","sequence":"first","affiliation":[{"name":"Department of Respiratory Diseases Terveystalo Hospital  Turku Finland"},{"name":"Department of Respiratory Diseases Turku University Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomo","family":"Rantanen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Alimentary Tract Surgery Tampere University Hospital  Tampere Finland"},{"name":"Department of Surgery Central Hospital of Sein\u00e4joki  Sein\u00e4joki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilmo","family":"Kellokumpu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Central Hospital of Central Finland  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiit","family":"K\u00f6\u00f6bi","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Tampere University Hospital  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauri","family":"Lammi","sequence":"additional","affiliation":[{"name":"Department of 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