{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:57:34Z","timestamp":1772812654299,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Comparisons of the characteristics between the influenza <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">H1N1<\/jats:styled-content>) pdm09 and common seasonal influenza are important for both clinical management and epidemiological studies. However, the differences between pandemic and seasonal influenza during the post\u2010pandemic period are poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of our research was to investigate clinical and immune response differences between patients with influenza <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">H1N1<\/jats:styled-content>) pdm09 pneumonia and seasonal influenza <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">H3N2<\/jats:styled-content>) pneumonia in the post\u2010pandemic period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During the first flu season in post\u2010pandemic period, patients from <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>eijing <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>etwork for <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>dult <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ommunity\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>cquired <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>neumonia present <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">H1N1<\/jats:styled-content>) pdm09 or <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">H3N2<\/jats:styled-content>) influenza were compared concurrently in the aspects of clinical characteristics and inflammatory profile in acute phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">H1N1<\/jats:styled-content>) pdm09 influenza pneumonia showed a close mean age to <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>2) pneumonia (51\u2009\u00b1\u200920 vs 53\u2009\u00b1\u200916, mean\u2009\u00b1\u2009standard deviation, years) but tended to have more underlying diseases (32.8% vs 10%, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.036). Although clinical characteristics were similar, no statistical difference were found in pneumonia severity index (<jats:styled-content style=\"fixed-case\">PSI<\/jats:styled-content>) score or intensive care unit admission rate or mortality, patients in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">H1N1<\/jats:styled-content>) pdm09 cohort present higher levels of aspartate aminotransferase, lactase dehydrogenase (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.006, 0.018, respectively) in blood and also longer duration of fever than <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">H3N2<\/jats:styled-content>) cohort. Levels of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201010 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012 (p70) were higher in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">H1N1<\/jats:styled-content>) pdm09 cohort (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.031, 0.047, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusios<\/jats:title><jats:p>During the first post\u2010pandemic flu season, patients with the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">H1N1<\/jats:styled-content>) pdm09 pneumonia showed similar clinical characteristics but slightly higher disease severity and stronger systemic inflammatory response than <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">H3N2<\/jats:styled-content>) pneumonia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12056","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T22:01:48Z","timestamp":1381528908000},"page":"185-191","source":"Crossref","is-referenced-by-count":21,"title":["Influenza pneumonia among adolescents and adults: a concurrent comparison between influenza <scp>A<\/scp> (<scp>H1N1<\/scp>) pdm09 and <scp>A<\/scp> (<scp>H3N2<\/scp>) in the post\u2010pandemic period"],"prefix":"10.1111","volume":"8","author":[{"given":"Shu Qiao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Chao\u2010Yang Hospital Beijing Institute of Respiratory Medicine Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiu Xin","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Chao\u2010Yang Hospital Beijing Institute of Respiratory Medicine Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Medicine Beijing Hospital Ministry of Heath  Beijing China"},{"name":"Department of Respiratory Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Respiratory Medicine  Beijing China"},{"name":"Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Min","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Chao\u2010Yang Hospital Beijing Institute of Respiratory Medicine Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Chao\u2010Yang Hospital Beijing Institute of Respiratory Medicine Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Chao\u2010Yang Hospital Beijing Institute of Respiratory Medicine Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.77a.10135"},{"key":"e_1_2_6_3_1","volume-title":"Global Alert and Response (GAR). 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