{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:10:25Z","timestamp":1769519425466,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Well\u2010differentiated papillary mesothelioma (<jats:styled-content style=\"fixed-case\">WDPM<\/jats:styled-content>) is a rare mesothelial tumour affecting mostly the peritoneum of women in their reproductive age, but it may occur also at other sites, including the pleura. It is considered a specific pathological entity different from diffuse malignant mesothelioma as it displays a characteristic histological pattern and is associated with a slowly progressive clinical course. We report the case of a 79\u2010year\u2010old man with a history of right pleural <jats:styled-content style=\"fixed-case\">WDPM<\/jats:styled-content> at age 64, which was successfully treated with chemotherapy, radiotherapy and talc pleurodesis. Thirteen years after the first diagnosis, he presented with mediastinal lymph nodes metastasis and with an extremely rare pattern of tracheal and bronchial infiltration that was detected at bronchoscopy. Biopsy samples revealed loss of histological differentiation of the neoplastic cells. This case report highlights that <jats:styled-content style=\"fixed-case\">WDPM<\/jats:styled-content> is a tumour of uncertain malignant potential that may undergo transformation over many years. Finally, the role of immunohistochemistry in the diagnosis of <jats:styled-content style=\"fixed-case\">WDPM<\/jats:styled-content> and the possible mechanisms leading to this unique way of metastatisation are discussed.<\/jats:p>","DOI":"10.1111\/crj.12057","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:09:29Z","timestamp":1381543769000},"page":"124-129","source":"Crossref","is-referenced-by-count":19,"title":["Malignant transformation of well\u2010differentiated papillary mesothelioma 13 years after the diagnosis: a case report"],"prefix":"10.1111","volume":"8","author":[{"given":"Luisa","family":"Costanzo","sequence":"first","affiliation":[{"name":"Chair of Geriatrics Unit of Respiratory Pathophysiology Campus Bio Medico University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Scarlata","sequence":"additional","affiliation":[{"name":"Chair of Geriatrics Unit of Respiratory Pathophysiology Campus Bio Medico University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Perrone","sequence":"additional","affiliation":[{"name":"Department of Pathology Campus Bio Medico University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Biotechnologies \u2018La Sapienza\u2019 University  Latina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anselmo","family":"Papa","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Biotechnologies \u2018La Sapienza\u2019 University  Latina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco Maria","family":"Di Matteo","sequence":"additional","affiliation":[{"name":"Gastro Intestinal Endoscopy Unit Campus Bio Medico University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Tonini","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Campus Bio Medico University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Onetti Muda","sequence":"additional","affiliation":[{"name":"Department of Pathology Campus Bio Medico University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Antonelli\u2010Incalzi","sequence":"additional","affiliation":[{"name":"Chair of Geriatrics Unit of Respiratory Pathophysiology Campus Bio Medico University  Rome Italy"},{"name":"Fondazione \u2018S. Raffaele \u2013 Cittadella della Carit\u00e0\u2019  Taranto Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silverio","family":"Tomao","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Biotechnologies \u2018La Sapienza\u2019 University  Latina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182354a79"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0096-5588(20)30819-9","article-title":"Localized pleural mesothelioma of epithelial type","volume":"26","author":"Yesner R","year":"1953","journal-title":"J Thorac Surg"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200110000-00012"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200404000-00013"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000196677"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181a97dc3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2009.10.004"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.5858\/133.8.1317"},{"key":"e_1_2_5_10_1","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of the Lung, Pleura, Thymus and Heart","author":"Travis WD","year":"2004"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.8523"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2005.03.017"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2012.08.005"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01606033"},{"key":"e_1_2_5_15_1","first-page":"517","article-title":"Malignant transformation of a well\u2010differentiated peritoneal papillary mesothelioma","volume":"47","author":"Hejmadi R","year":"2003","journal-title":"Acta Cytol"},{"key":"e_1_2_5_16_1","first-page":"731","article-title":"Appearance of mesothelioma cells in sputum. A case report","volume":"36","author":"Nakajima M","year":"1992","journal-title":"Acta Cytol"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326638"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12057","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T01:02:53Z","timestamp":1696294973000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.12057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,26]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/crj.12057"],"URL":"https:\/\/doi.org\/10.1111\/crj.12057","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,26]]}}}