{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:29:01Z","timestamp":1771475341330,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T00:00:00Z","timestamp":1389312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Since <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ebruary 2013, a novel reassortant <jats:styled-content style=\"fixed-case\">H7N<\/jats:styled-content>9 virus associated with human deaths, but no apparent outbreaks in poultry and wild birds has emerged in eastern <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The potential reemergence of <jats:styled-content style=\"fixed-case\">H7N<\/jats:styled-content>9 during next year's influenza season demand a further understanding of this important disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 1 and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 30, 2013, we obtained and analyzed clinical, epidemiologic and radiologic features, and virologic data from three laboratory\u2010confirmed patients of <jats:styled-content style=\"fixed-case\">A H7N<\/jats:styled-content>9 infection admitted in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>hanghai <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>uijin <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients were middle to old aged (mean age 62 years) and overweight (mean body mass index 31) patients. Two patients were exposed to poultry directly or indirectly in food market. They presented with fever and rapidly progressive pneumonia that did not respond to antibiotics. Time between onset of symptoms and onset of respiratory failure (days) were 7\u201311 days. Two patients presented secondary invasive bacterial infections. All patients died on day 7 to day 86 after the onset of symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cross species poultry\u2010to\u2010person transmission of this new reassortant avian influenza <jats:styled-content style=\"fixed-case\">H7N<\/jats:styled-content>9 virus can result in severe and fatal respiratory disease like acute respiratory distress syndrome (<jats:styled-content style=\"fixed-case\">ARDS<\/jats:styled-content>) in humans. Reduplicate chest imaging examination is suggested for risky patients with fever and dyspnea. Secondary invasive bacterial infections and pneumothorax can cause severe and fatal consequence. Old age, obesity and presence of comorbidity may be associated with increased mortality. Pulmonary fibrosis can be seen at late stage of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12087","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T10:47:08Z","timestamp":1386326828000},"page":"410-416","source":"Crossref","is-referenced-by-count":23,"title":["Clinical features of three avian influenza <scp>H7N<\/scp>9 virus\u2010infected patients in <scp>S<\/scp>hanghai"],"prefix":"10.1111","volume":"8","author":[{"given":"Xiao Fei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine School of Medicine Ruijin Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo Chao","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine School of Medicine Ruijin Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan 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