{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:00:34Z","timestamp":1773392434333,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>There are no larger studies of adults with osteogenesis imperfecta (OI<\/jats:styled-content>), focusing on the impact of spinal cord deformities on lung function assessment.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To assess prevalence and severity of spinal deformities and lung function in an adult population with OI<\/jats:styled-content> and to explore whether compromise of lung function correlated with deformities of the spine.<\/jats:p><\/jats:sec>Methods<\/jats:title>Ninety\u2010two adults with OI<\/jats:styled-content> had radiographs of the spine, 75 underwent spirometry. Deformities were assessed radiographically using a semi\u2010quantitative (SQ<\/jats:styled-content>) approach grading each vertebra from mild to severe (0\u20133 SQ<\/jats:styled-content> grades). The spinal deformity index (SDI<\/jats:styled-content>) was calculated by summing the SQ<\/jats:styled-content> grades of all vertebrae from TH<\/jats:styled-content>4 to L<\/jats:styled-content>4. Scoliosis was measured using the C<\/jats:styled-content>obb method. Pulmonary function tests were performed; both current measured and arm\u2010span height were used for calculating the predicted lung volumes and flow rates.<\/jats:p><\/jats:sec>Results<\/jats:title>Vertebral deformities were found in 67%, the majority of deformities were found in the mid thoracic region. Scoliosis was found in 46%, nine patients exhibited torsion scoliosis. Median values of SDI<\/jats:styled-content> were 2.0 in type I<\/jats:styled-content>, 4.0 in type IV<\/jats:styled-content> and 2.5 in the total population. Only correction with arm\u2010span height had a significant impact on the assessment of lung function. Significant negative correlations were obtained when spirometry variables were correlated to spine deformities.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>OI<\/jats:styled-content> patients show spinal deformities influencing body height and lung function. Lung function tests should be corrected for reductions in body height by using arm\u2010span height. OI<\/jats:styled-content> patients should be evaluated with spirometry when vertebral deformities are suspected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12092","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T11:03:01Z","timestamp":1386327781000},"page":"437-443","source":"Crossref","is-referenced-by-count":48,"title":["Spinal deformities and lung function in adults with osteogenesis imperfecta"],"prefix":"10.1111","volume":"8","author":[{"given":"Lena L.","family":"Wekre","sequence":"first","affiliation":[{"name":"TRS National Resouce Centre for Rare Disorders Sunnaas Rehabilitation Hospital Bj\u00f8rnemyr Nesoddtangen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aina","family":"Kjensli","sequence":"additional","affiliation":[{"name":"Glittreklinikken Hakadal Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjersti","family":"Aasand","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A.","family":"Falch","sequence":"additional","affiliation":[{"name":"Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik F.","family":"Eriksen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16051-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.43.020192.001413"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199602000-00007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31811ec2d9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199908150-00008"},{"key":"e_1_2_7_7_1","unstructured":"GlorieuxF.Guide to osteogenesis imperfecta for pediatricians and family practice physicians2007. 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