{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:46:18Z","timestamp":1747212378890},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T00:00:00Z","timestamp":1389571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fundo de Incentivo \u00ef\u00bf\u00bd Pesquisa e Eventos do Hospital de Cl\u00ef\u00bf\u00bdnical de Porto Alegre","award":["5000"],"award-info":[{"award-number":["5000"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Cystic fibrosis (CF<\/jats:styled-content>) patients have a susceptibility to vitamin D<\/jats:styled-content> deficiency because of nutrient malabsorption.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To evaluate the prevalence of hypovitaminosis D<\/jats:styled-content> in CF<\/jats:styled-content> patients and the factors associated with serum 25\u2010hydroxyvitamin D<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>Methods<\/jats:title>We evaluated the prevalence of vitamin D<\/jats:styled-content> deficiency defined as 25\u2010hydroxyvitamin D<\/jats:styled-content> <30\u2009ng\/mL<\/jats:styled-content>, as suggested recently by the C<\/jats:styled-content>ystic F<\/jats:styled-content>ibrosis F<\/jats:styled-content>oundation, and factors associated with its serum levels. Patients with confirmed CF<\/jats:styled-content> were included. Nutritional status and hospital admissions were evaluated. Serum C<\/jats:styled-content>\u2010reactive protein, calcium, phosphate, magnesium, albumin, 25\u2010hydroxyvitamin D<\/jats:styled-content> and parathyroid hormone levels were measured. Lung function was evaluated by spirometry, and clinical and chest radiographic scores were assessed. Statistical significance level was set at P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.05.<\/jats:p><\/jats:sec>Results<\/jats:title>Fifty\u2010nine patients were included. Prevalence of hypovitaminosis D<\/jats:styled-content> was 61%. Patients with pancreatic insufficiency had a trend to have higher vitamin D<\/jats:styled-content> levels. Sixteen patients had severe lung disease with percentage of forced expiratory volume in 1\u2009s predicted below 40%. After multivariate analysis, body mass index and hospitalization in the last month remained significantly associated with serum vitamin D<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Vitamin D<\/jats:styled-content> insufficiency is still a problem in CF<\/jats:styled-content> patients, even in those receiving supplementation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12097","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T07:06:52Z","timestamp":1387350412000},"page":"455-459","source":"Crossref","is-referenced-by-count":5,"title":["Hypovitaminosis D<\/scp> in patients with cystic fibrosis: a cross\u2010section study in S<\/scp>outh B<\/scp>razil"],"prefix":"10.1111","volume":"8","author":[{"given":"Nat\u00e1lia Aydos","family":"Marcondes","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Medicina Ci\u00eancias M\u00e9dicas Universidade Federal do Rio Grande do Sul Porto Alegre 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