{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:09:53Z","timestamp":1770293393961,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T00:00:00Z","timestamp":1397520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Hyperinflation of the native lung (NLH<\/jats:styled-content>) is a known complication to single\u2010lung transplantation for emphysema. The hyperinflation can lead to compression of the graft and cause respiratory failure. Endobronchial valves have been used to block airflow in specific parts of the native lung, reducing the native lung volume and relieving the graft.<\/jats:p><\/jats:sec>Objective<\/jats:title>We report short\u2010term follow\u2010up and safety from 14 single\u2010lung transplant patients with NLH<\/jats:styled-content> treated with bronchoscopic lung volume reduction using endobronchial valves.<\/jats:p><\/jats:sec>Methods<\/jats:title>Retrospective clinical information related to endobronchial valve treatment was obtained from four centres. All patients were treated with IBV<\/jats:styled-content>TM<\/jats:sup> V<\/jats:styled-content>alve S<\/jats:styled-content>ystem (S<\/jats:styled-content>piration, O<\/jats:styled-content>lympus R<\/jats:styled-content>espiratory A<\/jats:styled-content>merica, R<\/jats:styled-content>edmond, WA<\/jats:styled-content>, USA<\/jats:styled-content>). All patients had evidence of severe NLH<\/jats:styled-content> with mediastinal displacement.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 74 IBV<\/jats:styled-content> valves were placed in 14 patients, with an average of 5.3 (range 2\u201310). Five patients had two procedures with staged treatment. Eleven patients reported symptom relief, and nine had lung function improvements. There was a significant increase in forced expiratory volume in 1\u2009s of 9% (P<\/jats:italic>\u2009=\u20090.013) and forced vital capacity of 15% (P<\/jats:italic>\u2009=\u20090.034) within the first months after treatment. There were no reported device\u2010related adverse events nor reports of migration. Two patients had pneumothorax. One patient had pneumonia in the location of the valve placement, and another had infection within days. Three other patients were hospitalised with infection 2 months after treatment.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Treating NLH<\/jats:styled-content> with IBV<\/jats:styled-content> endobronchial valves leads to clinical improvement in the majority of patients, and the treatment has an acceptable safety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12116","type":"journal-article","created":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T06:53:34Z","timestamp":1391842414000},"page":"104-110","source":"Crossref","is-referenced-by-count":14,"title":["Endoscopic treatment of native lung hyperinflation using endobronchial valves in single\u2010lung transplant patients: a multinational experience"],"prefix":"10.1111","volume":"9","author":[{"given":"Michael","family":"Perch","sequence":"first","affiliation":[{"name":"Department of Cardiology, Section for Lung Transplantation Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerdt C.","family":"Riise","sequence":"additional","affiliation":[{"name":"University of Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Hogarth","sequence":"additional","affiliation":[{"name":"Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali I.","family":"Musani","sequence":"additional","affiliation":[{"name":"University of Colorado Denver CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C.","family":"Springmeyer","sequence":"additional","affiliation":[{"name":"Spiration Inc. Redmond WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Spiration Inc. Redmond WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Section for Lung Transplantation Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904083401406"},{"issue":"2","key":"e_1_2_6_3_1","first-page":"192","article-title":"Single lung transplantation for emphysema: predictors for native lung hyperinflation","volume":"17","author":"Yonan NA","year":"1998","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs086"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs066"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.10.069"},{"issue":"6","key":"e_1_2_6_7_1","first-page":"895","article-title":"[Single lung transplantation with concomitant contralateral lung volume reduction for end\u2010stage emphysema]","volume":"27","author":"Shen Y","year":"2007","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1171"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.12.071"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.06.011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs352"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132010000200017"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.01.712"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2009.02.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.07.093"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900928"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200407-961OC"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)00398-4"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:45:48Z","timestamp":1696311948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.12116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,15]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/crj.12116"],"URL":"https:\/\/doi.org\/10.1111\/crj.12116","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,15]]}}}