{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:08:13Z","timestamp":1778670493853,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T00:00:00Z","timestamp":1397520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Tuberculosis (<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>) is an infectious disease with a global distribution. The mainstay of treatment is a combination of antituberculous (<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>) drugs. The standard combination uses four first\u2010line <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> drugs; however, in certain groups of patients, the combination must be modified or reduced in dosage. This is especially true of patients with comorbidities, in the elderly and in pregnant women. The aim of this review is to provide up\u2010to\u2010date information regarding <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> treatment in a variety of special patient populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Source<\/jats:title><jats:p>The recommendations presented here are based on the clinical experience of the author, as well as data presented in textbooks, <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>orld <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>rganization national and international guidelines, various respiratory societies and original articles quoted in medical databases. The time frame for this review was from 1995 to 2013. The data search was carried out only in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nglish and the index words were as follows: tuberculosis \u2013 treatment \u2013 liver disease \u2013 kidney disease \u2013 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection \u2013 skin toxicity \u2013 elderly \u2013 pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on our experience and the described sources above, we present <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> treatment recommendations for specific patient populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> can be difficult to diagnose and treat. This can be especially true in patients with comorbidities, adverse reactions to <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> drugs, the elderly and pregnant women. Despite the difficulties, an early diagnosis followed immediately by <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> treatment should be the norm for these patients. When choosing a suitable <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> regimen, we must consider the potential side effects of the drugs, which could exacerbate an underlying comorbidity, harm an expectant mother or fetus, or adversely affect the elderly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12119","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T08:50:54Z","timestamp":1392281454000},"page":"143-152","source":"Crossref","is-referenced-by-count":11,"title":["Challenges of antituberculosis treatment in patients with difficult clinical conditions"],"prefix":"10.1111","volume":"9","author":[{"given":"Martina","family":"Vasakova","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Thomayer Hospital Prague  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2011.02.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00033010"},{"key":"e_1_2_10_4_1","volume-title":"Treatment of Tuberculosis. 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