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The purpose of the study is to explore the clinical characteristics of non\u2010acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical symptoms, cough symptom score, capsaicin cough sensitivity, gastroesophageal reflux diagnostic questionnaire (<jats:styled-content style=\"fixed-case\">GerdQ<\/jats:styled-content>) score, findings of multichannel intraluminal impedance\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring (<jats:styled-content style=\"fixed-case\">MII<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>) and response to pharmacological anti\u2010reflux therapy were retrospectively reviewed in 38 patients with non\u2010acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content> and compared with those of 49 patients with acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Non\u2010acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content> had the similar cough character, cough symptom score, and capsaicin cough sensitivity to acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content>. However, non\u2010acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content> had less frequent regurgitation (15.8% vs 57.1%, \u03c7<jats:sup>2<\/jats:sup>\u2009=\u200913.346, <jats:italic>P<\/jats:italic>\u2009=\u20090.000) and heartburn (7.9% vs 32.7%, \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20097.686, <jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content>\u2009\u2009=\u20090.006), and lower <jats:styled-content style=\"fixed-case\">GerdQ<\/jats:styled-content> score (7.4\u2009\u00b1\u20091.4 vs 10.6\u2009\u00b1\u20092.1, <jats:italic>t<\/jats:italic>\u2009=\u2009\u22126.700, <jats:italic>P<\/jats:italic>\u2009=\u20090.003) than acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content>. Moreover, <jats:styled-content style=\"fixed-case\">MII<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> revealed more weakly acidic reflux episodes, gas reflux episodes and a higher symptom association probability (<jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content>) for non\u2010acid reflux but lower <jats:styled-content style=\"fixed-case\">DeMeester<\/jats:styled-content> score, acidic reflux episodes and <jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content> for acid reflux in non\u2010acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content> than in acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content>. Non\u2010acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content> usually responded to the standard anti\u2010reflux therapy but with delayed cough resolution or attenuation when compared with acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content>. Fewer patients with non\u2010acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content> needed an augmented acid suppressive therapy or treatment with baclofen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There are some differences in the clinical manifestations between non\u2010acid and acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content>, but <jats:styled-content style=\"fixed-case\">MII<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> is essential to diagnose non\u2010acid <jats:styled-content style=\"fixed-case\">GERC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12124","type":"journal-article","created":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T01:30:24Z","timestamp":1392946224000},"page":"196-202","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of clinical characteristics of chronic cough due to non\u2010acid and 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