{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:26:53Z","timestamp":1758817613705},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hurg\u2013<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>trauss syndrome (<jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>) is a rare multisystem vasculitis. Considering the variation of autoimmune diseases in different races, it is of interest to determine whether any outstanding features exist for <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>urkish patients with <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the clinical and serological features of the disease, the treatment, and long\u2010term follow\u2010up details, and to investigate possible etiological factors of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>urkish <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 14 patients who were diagnosed with <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>, and followed by our department between 2004 and 2012. Possible etiological factors, initial symptoms, clinical presentations, treatment, as well as outcomes were documented. The study was approved by the local ethics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients fulfilled the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merican <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ollege of <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>heumatology criteria. Initial symptoms were worsening asthma (<jats:italic>n<\/jats:italic>\u2009=\u200914; 100%) and skin lesions (<jats:italic>n<\/jats:italic>\u2009=\u20096; 43%). All patients had a diagnosis of asthma and nasal polyps, whereas 57.1% had aspirin hypersensitivity at the time of diagnosis. The lungs (100%) and skin (43%) were most commonly involved. Peripheral eosinophilia dominated on initial presentations of all patients. Initial treatments included oral methyl prednisolone in all cases, whereas cyclophosphamide and azathioprine were used in three cases. Relapses were detected in five cases. None of the cases were able to stop the oral corticosteroid treatment. No fatalities were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We herein describe a new severe asthma endotype in connection with <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>. We suggest that physicians who deal with uncontrolled severe asthma cases should consider <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> in the presence of nasal polyps, aspirin hypersensitivity, and especially peripheral blood eosinophilia over 10%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12154","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T03:30:47Z","timestamp":1398396647000},"page":"350-358","source":"Crossref","is-referenced-by-count":2,"title":["<scp>C<\/scp>hurg\u2013<scp>S<\/scp>trauss syndrome: a new endotype of severe asthma? 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